CAJ | 학술논문

iNKT细胞是T细胞的一个亚群,表达T细胞表面受体(TCR)和NK细胞表面标志物NK1.1(人类为CD161),能够被非经典MHC-I类分子CDld提呈的糖脂抗原所激活,不仅具有T细胞的免疫调节作用,也具有NK细胞的自然杀伤作用.近年来的研究发现iNKT细胞在多种自身免疫性疾病,包括系统性红斑狼疮(Systemic Lupus Erythematosus,SLE)的发生中扮演重要角色,但具体机制还不明确.
iNKT세포시T세포적일개아군,표체T세포표면수체(TCR)화NK세포표면표지물NK1.1(인류위CD161),능구피비경전MHC-I류분자CDld제정적당지항원소격활,불부구유T세포적면역조절작용,야구유NK세포적자연살상작용.근년래적연구발현iNKT세포재다충자신면역성질병,포괄계통성홍반랑창(Systemic Lupus Erythematosus,SLE)적발생중분연중요각색,단구체궤제환불명학.
Invariant natural killer T cells(iNKT)is a unique T cell lineage,which bearing an invariant T cell veceptcor(TCR)and NK1.1(human CD161),and can recognize a small variety of glycolipid antigens when CD1d(non-classical MHC-I)presents.iNKT cells play a regulatory role during immune responses by producing cytokines,and have the ability to destroy other cells as NK cells.Despite the ambiguous mechanism,recent researches show that iNKT plays all vital role in many autoimmune diseases including systemic lupus erythematosus(SLE).