白血病·淋巴瘤
白血病·淋巴瘤
백혈병·림파류
JOURNAL OF LEUKEMIA & LYMPHOMA
2009年
4期
197-200
,共4页
任丽娟%张巧花%施静艺%张群岭%姜晓星%侯淑玲%黄云鹏%赵维莅
任麗娟%張巧花%施靜藝%張群嶺%薑曉星%侯淑玲%黃雲鵬%趙維蒞
임려연%장교화%시정예%장군령%강효성%후숙령%황운붕%조유리
淋巴瘤,非霍奇金%多态性,单核苷酸%易感性%XRCCl
淋巴瘤,非霍奇金%多態性,單覈苷痠%易感性%XRCCl
림파류,비곽기금%다태성,단핵감산%역감성%XRCCl
Lymphoma,non-Hodgkin%Polymorphism,single nucleotide%Susceptibility%XRCCl
目的 探讨DNA修复基因XRCCl R280H、XRCCl TSS+29C/T单核苷酸多态性与非霍奇金淋巴瘤(NHL)易感性的关系.方法 运用MassARRAY技术对73例NHL病例和540名健康对照的DNA修复基因XRCCl多态性进行检测,比较其不同基因型与淋巴瘤患病风险的关系.结果 XRCClR280H中G、A基因频率在对照组和病例组中分布差异有统计学意义(P=0.001),而XRCClTSS+29C/T中T、C的基因频率在两组中的分布差异无统计学意义(P=0.383).进一步的分析表明,在XRCCl R280H中,与携带GG野生纯合子基因型者比较,携带至少一个A等位基因者(GA或AA)患淋巴瘤的风险显著降低(P＜0.001,OR=0.309,95%CI=0.168～0.567).而在XRCCl TSS+29C/T中,CC和CT与基因TT比较,携带C基因者会增加淋巴瘤的发病风险(P=0.472,OR=1.262,95%CI/=0.669～2.379).结论 DNA修复基因XRCCl R280H的基因多态性与NHL的发生密切相关.
目的 探討DNA脩複基因XRCCl R280H、XRCCl TSS+29C/T單覈苷痠多態性與非霍奇金淋巴瘤(NHL)易感性的關繫.方法 運用MassARRAY技術對73例NHL病例和540名健康對照的DNA脩複基因XRCCl多態性進行檢測,比較其不同基因型與淋巴瘤患病風險的關繫.結果 XRCClR280H中G、A基因頻率在對照組和病例組中分佈差異有統計學意義(P=0.001),而XRCClTSS+29C/T中T、C的基因頻率在兩組中的分佈差異無統計學意義(P=0.383).進一步的分析錶明,在XRCCl R280H中,與攜帶GG野生純閤子基因型者比較,攜帶至少一箇A等位基因者(GA或AA)患淋巴瘤的風險顯著降低(P＜0.001,OR=0.309,95%CI=0.168～0.567).而在XRCCl TSS+29C/T中,CC和CT與基因TT比較,攜帶C基因者會增加淋巴瘤的髮病風險(P=0.472,OR=1.262,95%CI/=0.669～2.379).結論 DNA脩複基因XRCCl R280H的基因多態性與NHL的髮生密切相關.
목적 탐토DNA수복기인XRCCl R280H、XRCCl TSS+29C/T단핵감산다태성여비곽기금림파류(NHL)역감성적관계.방법 운용MassARRAY기술대73례NHL병례화540명건강대조적DNA수복기인XRCCl다태성진행검측,비교기불동기인형여림파류환병풍험적관계.결과 XRCClR280H중G、A기인빈솔재대조조화병례조중분포차이유통계학의의(P=0.001),이XRCClTSS+29C/T중T、C적기인빈솔재량조중적분포차이무통계학의의(P=0.383).진일보적분석표명,재XRCCl R280H중,여휴대GG야생순합자기인형자비교,휴대지소일개A등위기인자(GA혹AA)환림파류적풍험현저강저(P＜0.001,OR=0.309,95%CI=0.168～0.567).이재XRCCl TSS+29C/T중,CC화CT여기인TT비교,휴대C기인자회증가림파류적발병풍험(P=0.472,OR=1.262,95%CI/=0.669～2.379).결론 DNA수복기인XRCCl R280H적기인다태성여NHL적발생밀절상관.
Objective To investigate the correlation between XRCC1 R280H,XRCCl TSS+29C/T genetic polymorphisma and susceptibility to non-Hodgkin lymphoma (NHL). Methods The MassARRAY method was applied to detect the DNA repair gene XRCC1 genetic polymorphisms in 73 cases of NHL and 540 cases of normal healthy controls. Chi-square test was performed to calculate the adjusted odds ratios (OR) and 95% confidence intervals (CI). Results For XRCCl R280H genotypes, there was a significant difference between frequencies of the G and A among patients and controls (P=0.001). However, XRCCl TSS+29C/T genotypes had no statistical difference as for the T and C frequencies between patients and controls (P = 0.383). The frequency of XRCCI R280H with at least one A genotype was lower in the NHL cases than in controls, indicating a decreased risk for NHL development (OR=0.309, 95 % CI =0.168-0.567), comparing with GG genotype. In XRCC1 TSS+29C/T genotypes, the frequeney of TC and CC genotype was higher in NHL cases than in controls and associated with an increased risk of NHL development (P=0.472, OR =1.262, 95 % CI =0.669-2.379). Conclusion DNA repair XRCCl gene possesses significant correlation with NHL.
