国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2010年
11期
1295-1297
,共3页
许美芳%吴惠平%钟兰英%刘和录%董功航
許美芳%吳惠平%鐘蘭英%劉和錄%董功航
허미방%오혜평%종란영%류화록%동공항
生理盐水%冲管%隔开%配伍禁忌药物%静脉输液%安全性
生理鹽水%遲管%隔開%配伍禁忌藥物%靜脈輸液%安全性
생리염수%충관%격개%배오금기약물%정맥수액%안전성
Saline%Tube washing%Separation%Incompatible drugs%Intravenous infusion%Safety
目的 观察生理盐水冲管隔开有配伍禁忌药物静脉输液的可行性.方法 选取符合纳入研究对象标准、有配伍禁忌的药物三对,进行"直接混合试验"和"生理血液浓度模拟试验",观察其外观、PH值、沉淀物的变化.结果 阿莫西林,舒巴坦+盐酸氨溴索不同时间可有不一样的试验结果可能与药物批号不同有关;炎琥宁+维生素B6注射液直接混合有白色悬浮沉淀,但在模拟试验下未见白色悬浮沉淀.结论 有配伍禁忌的药物存在可变性与药物批号有关;有配伍禁忌的药物在模拟生理血液浓度下可无反应.
目的 觀察生理鹽水遲管隔開有配伍禁忌藥物靜脈輸液的可行性.方法 選取符閤納入研究對象標準、有配伍禁忌的藥物三對,進行"直接混閤試驗"和"生理血液濃度模擬試驗",觀察其外觀、PH值、沉澱物的變化.結果 阿莫西林,舒巴坦+鹽痠氨溴索不同時間可有不一樣的試驗結果可能與藥物批號不同有關;炎琥寧+維生素B6註射液直接混閤有白色懸浮沉澱,但在模擬試驗下未見白色懸浮沉澱.結論 有配伍禁忌的藥物存在可變性與藥物批號有關;有配伍禁忌的藥物在模擬生理血液濃度下可無反應.
목적 관찰생리염수충관격개유배오금기약물정맥수액적가행성.방법 선취부합납입연구대상표준、유배오금기적약물삼대,진행"직접혼합시험"화"생리혈액농도모의시험",관찰기외관、PH치、침정물적변화.결과 아막서림,서파탄+염산안추색불동시간가유불일양적시험결과가능여약물비호불동유관;염호저+유생소B6주사액직접혼합유백색현부침정,단재모의시험하미견백색현부침정.결론 유배오금기적약물존재가변성여약물비호유관;유배오금기적약물재모의생리혈액농도하가무반응.
Objective To explore the feasibility of separating intravenous infusions of incompatible drugs by tube washing with normal saline. Methods We select three pairs of incompatible drugs the study based on the trial criteria to carry out a 'direct mixing test' and a 'simulation test of physiological blood concentration'. The changes in appearance, PH value, and sediment of the incompatible solutions were observed. Results Amoxicillin/ sulbactam mixed with ambroxol revealed different results at different time points, which may be related to different time of production; Yanhuning mixed with Vitamin B6 developed white suspending sediment, but this sediment was found on the simulation test. Conclusions Incompatible drugs have changeability which may be related with time of production. Those drugs may not develop reactions on the simulation test.