中华临床感染病杂志
中華臨床感染病雜誌
중화림상감염병잡지
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
2009年
3期
143-146
,共4页
肝炎表面抗原%乙型%化学发光微粒子免疫分析%定量检测
肝炎錶麵抗原%乙型%化學髮光微粒子免疫分析%定量檢測
간염표면항원%을형%화학발광미입자면역분석%정량검측
Hepatitis B surface antigens%Chemiluminescent microparticle immunoassay%Quantitative detection
目的 探讨血清HBsAg定量检测的临床应用价值.方法 采用化学发光微粒子免疫分析技术定量测定7612例非肝炎相关病区住院患者的血清HBsAg浓度,分析血清HBsAg水平的人群分布特征及与其他HBV血清学标志物(抗-HBs、HBeAg)和HBV DNA之间的关系.结果 870例患者检出血清HBsAg阳性,阳性率为11.4%(870/7612),浓度范围为0.08～125 000.00 U/mL,中位数值为932.28 U/mL.比较男、女患者血清HBsAg浓度差异无统计学意义(Z=-0.366,P＞0.05).血清HBsAg浓度与患者年龄呈负相关(r=-0.370,P＜0.01),与血清HBeAg和HBV DNA水平呈正相关(r分别为0.654和0.765,P值均＜0.01).结论 血清HBsAg定量检测有利于精确反映乙型肝炎患者HBV复制和清除情况.
目的 探討血清HBsAg定量檢測的臨床應用價值.方法 採用化學髮光微粒子免疫分析技術定量測定7612例非肝炎相關病區住院患者的血清HBsAg濃度,分析血清HBsAg水平的人群分佈特徵及與其他HBV血清學標誌物(抗-HBs、HBeAg)和HBV DNA之間的關繫.結果 870例患者檢齣血清HBsAg暘性,暘性率為11.4%(870/7612),濃度範圍為0.08～125 000.00 U/mL,中位數值為932.28 U/mL.比較男、女患者血清HBsAg濃度差異無統計學意義(Z=-0.366,P＞0.05).血清HBsAg濃度與患者年齡呈負相關(r=-0.370,P＜0.01),與血清HBeAg和HBV DNA水平呈正相關(r分彆為0.654和0.765,P值均＜0.01).結論 血清HBsAg定量檢測有利于精確反映乙型肝炎患者HBV複製和清除情況.
목적 탐토혈청HBsAg정량검측적림상응용개치.방법 채용화학발광미입자면역분석기술정량측정7612례비간염상관병구주원환자적혈청HBsAg농도,분석혈청HBsAg수평적인군분포특정급여기타HBV혈청학표지물(항-HBs、HBeAg)화HBV DNA지간적관계.결과 870례환자검출혈청HBsAg양성,양성솔위11.4%(870/7612),농도범위위0.08～125 000.00 U/mL,중위수치위932.28 U/mL.비교남、녀환자혈청HBsAg농도차이무통계학의의(Z=-0.366,P＞0.05).혈청HBsAg농도여환자년령정부상관(r=-0.370,P＜0.01),여혈청HBeAg화HBV DNA수평정정상관(r분별위0.654화0.765,P치균＜0.01).결론 혈청HBsAg정량검측유리우정학반영을형간염환자HBV복제화청제정황.
Objective To investigate the clinical significance of quantitative detection of serum HBsAg.Methods Serum concentrations of HBsAg were detected by chemiluminescent microparticle immunoassay in 7612 hospitalized non-hepatitis patients.The distribution of HBsAg positive patients and the relationship of HBsAg concentration with serum anti.HBs.HBeAg and HBV DNA were analyzed.Results The HBsAg positive rate was 11.4%(870/7612)in this series.The serum HBsAg ranged from 0.08 U/mL to 125 000 U/mL with a median of 932.28 U/mL.No significant difference of HBsAg concentrations between male and female patients was observed(Z=-0.366,P＞0.05).1.There were negative correlation of HBsAg concentration with the age of patients(r=-0.370,P＜0.01),and positive correlations of HBsAg with HBeAg(r=0.654,P＜0.01)and HBV DNA levels(r=0.765,P＜0.01).Conclusion The quantitative determination of seFum HBsAg may be useful in estimating the hepatitis B viral replication and clearance.
