中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2008年
5期
345-348
,共4页
赵德利%李会庆%纪鹏%周瑞雪%雷复华%刁玉涛%李颢%杨艳芳%周英智%王燕%尹畅%房学强
趙德利%李會慶%紀鵬%週瑞雪%雷複華%刁玉濤%李顥%楊豔芳%週英智%王燕%尹暢%房學彊
조덕리%리회경%기붕%주서설%뢰복화%조옥도%리호%양염방%주영지%왕연%윤창%방학강
食管肿瘤%癌前状态%染色与标记%普查%数据说明,统计
食管腫瘤%癌前狀態%染色與標記%普查%數據說明,統計
식관종류%암전상태%염색여표기%보사%수거설명,통계
Esophageal neoplasms%Precancerous conditions%Staining and labeling%Mass screening%Deta interpretaion,statistical
目的 观察食管癌高发区社区居民食管癌前状态和病变的分布情况,为该病的病因及二级预防提供依据.方法 在山东省肥城市食管癌高发社区,对9536名高危人群采用碘染色内镜普查,取活检1507例进行食管癌各种病变的病理诊断.对病理活检结果按性别及年龄分布的构成比和各疾病的检出率比较采用χ2检验.结果 1507例活检病理诊断分类的男女构成比差异没有统计学意义.将轻、中度不典型增生为癌前状态、重度不典型增生为癌前病变划分,以所有参加普查人数为分母,男性食管癌前状态和癌前病变的检出率分别为6.98%(294/4214)和1.23%(52/4214),而女性则分别为3.68%(196/5322)和0.47%(25/5322);男女比较,χ2值分别为52.349和15.267,P值均＜0.05,差异均有统计学意义.按年龄组分析,重度不典型增生病变主要分布在50～岁到65～岁年龄组,原位癌是45～到50～岁年龄组的构成比最高,早期癌主要分布在45～到65～岁5个年龄组.按乡镇分布分析显示,高发乡镇食管癌前病变和癌的检出率高.结论 该地区居民食管癌前状态和病变的分布情况为该地食管癌的一、二级预防提供了科学基础.
目的 觀察食管癌高髮區社區居民食管癌前狀態和病變的分佈情況,為該病的病因及二級預防提供依據.方法 在山東省肥城市食管癌高髮社區,對9536名高危人群採用碘染色內鏡普查,取活檢1507例進行食管癌各種病變的病理診斷.對病理活檢結果按性彆及年齡分佈的構成比和各疾病的檢齣率比較採用χ2檢驗.結果 1507例活檢病理診斷分類的男女構成比差異沒有統計學意義.將輕、中度不典型增生為癌前狀態、重度不典型增生為癌前病變劃分,以所有參加普查人數為分母,男性食管癌前狀態和癌前病變的檢齣率分彆為6.98%(294/4214)和1.23%(52/4214),而女性則分彆為3.68%(196/5322)和0.47%(25/5322);男女比較,χ2值分彆為52.349和15.267,P值均＜0.05,差異均有統計學意義.按年齡組分析,重度不典型增生病變主要分佈在50～歲到65～歲年齡組,原位癌是45～到50～歲年齡組的構成比最高,早期癌主要分佈在45～到65～歲5箇年齡組.按鄉鎮分佈分析顯示,高髮鄉鎮食管癌前病變和癌的檢齣率高.結論 該地區居民食管癌前狀態和病變的分佈情況為該地食管癌的一、二級預防提供瞭科學基礎.
목적 관찰식관암고발구사구거민식관암전상태화병변적분포정황,위해병적병인급이급예방제공의거.방법 재산동성비성시식관암고발사구,대9536명고위인군채용전염색내경보사,취활검1507례진행식관암각충병변적병리진단.대병리활검결과안성별급년령분포적구성비화각질병적검출솔비교채용χ2검험.결과 1507례활검병리진단분류적남녀구성비차이몰유통계학의의.장경、중도불전형증생위암전상태、중도불전형증생위암전병변화분,이소유삼가보사인수위분모,남성식관암전상태화암전병변적검출솔분별위6.98%(294/4214)화1.23%(52/4214),이녀성칙분별위3.68%(196/5322)화0.47%(25/5322);남녀비교,χ2치분별위52.349화15.267,P치균＜0.05,차이균유통계학의의.안년령조분석,중도불전형증생병변주요분포재50～세도65～세년령조,원위암시45～도50～세년령조적구성비최고,조기암주요분포재45～도65～세5개년령조.안향진분포분석현시,고발향진식관암전병변화암적검출솔고.결론 해지구거민식관암전상태화병변적분포정황위해지식관암적일、이급예방제공료과학기출.
Objective To observe the distribution of the pre-cancerous condition and pathological changes of esophageal cancer of the community residents in high-incidence area, and to provide etiological evidences for secondary prevention. Methods An iodine-staining endoscope census was conducted in 9536 residents with high-risk factors at Feicheng, a high esophageal cancer incidence community in Shandong province. Of which, 1507 pathologic biopsies were performed and χ2 test administrated. Results There was no statistical significance found in biopsy pathologic diagnosis between females and males among 1507 samples. The mild and medium atypical hyperplasia was taken as pre-cancerous condition and severe atypical hyperplasia was taken as pre-caneerous lesion. Taking all the population attending census as denominator,the detection rate of the precancerous state and precancerous lesion were 6.98% (294/4214) and 1.23% (52/4214) for the males, and 3.68% (196/5322)and 0. 47% (25/5322)for the females, respectively. A statistical significance was observed when comparing males with females ( χ2 were 52. 349 and 15. 267,respectively, P ＜ 0. 05 ). Analyzed by age group, severe atypical hyperplasia pathological changes were mainly distributed in the age group of 50 - and 65 -. The constituent ratio between 45 - and 50 - was the highest for CIS. Early carcinoma was mainly distributed in five age groups from 45 - to 65 -. It showed that high incidence town had a high detection rate of cancer and pathological changes of esophageal cancer in the analysis of urban and rural distribution. Conclusion The distribution of the pre-cancerous state and pathological changes of esophageal cancer of the residents should have provided a scientific basis for the primary and secondary prevention.
