CAJ | 학술논문

目的探讨针灸对骨质疏松性骨质愈合的作用。方法采用12月龄雌性大鼠60只，摘除双侧卵巢法建立骨质疏松模型，造模3个月后作右股骨中段闭合骨折，随机分为对照组、模型组、雌二醇组、针刺组、艾灸组，分别于骨折后7、14、28天处死，并进行血清生化、骨痂BMP和组织学的观察。结果骨折后第14天S-E2、S-BGP含量及BMP光密度值，针刺组和艾灸组较模型组之间的差别有显著性意义（P＜0.05），至28天接近对照组；14天时软骨细胞及破骨细胞数量模型组较针刺组、艾灸组和雌二醇组稍多；28天时，各组骨痂均较成熟，但模型组呈疏松化表现。结论针灸具有促进骨质疏松性骨质愈合的作用。
목적탐토침구대골질소송성골질유합적작용。방법채용12월령자성대서60지，적제쌍측란소법건립골질소송모형，조모3개월후작우고골중단폐합골절，수궤분위대조조、모형조、자이순조、침자조、애구조，분별우골절후7、14、28천처사，병진행혈청생화、골가BMP화조직학적관찰。결과골절후제14천S-E2、S-BGP함량급BMP광밀도치，침자조화애구조교모형조지간적차별유현저성의의（P＜0.05），지28천접근대조조；14천시연골세포급파골세포수량모형조교침자조、애구조화자이순조초다；28천시，각조골가균교성숙，단모형조정소송화표현。결론침구구유촉진골질소송성골질유합적작용。
Objective To investigate therapeutical effect of acupuncture and moxibustion on fracture healing of osteoporosis in animal models．Methods Female rats aged 12 months were ovariectomized bilaterally for the production of osteoporotic models，closed fracture were produced at middle shaft of the right femur three months after bilateral ovariectomy．Then they were divided randomly into 5 groups：control group，model group，estradiol group，acupuncture group and moxibustion group．The animals were sacrificed at 7，14 and 28 days after fracture．Histological study，serum biochemical examination，bone morphogenetic protein（BMP） in callus were observed．Results Serum estradiol（S-E2），serum bone growth protein （S-BGP） and light density of BMP in acupuncture group and moxibustion group were significantly higher than those of model group（P＜0.05） on the 14th day after fracture．On the 28th day，S-E2，S-BGP and BMP in acupuncture group and moxibustion group were close to those of control group．On the 14th day，the amount of cartilage cells and osteoclasts in the model group was a little more than that of acupuncture group，moxibustion group and estradiol group．On the 28th day，calluses were all mature in each group，however，only in the model group they were in porous．Conclusion Acupuncture and moxibustion have the effect of promoting fracture healing in animal models of osteoporsis．