CAJ | 학술논문

目的检测云南大理地区白族与汉族对照人群及2型糖尿病(T2DM)患者脂联素基因(APM1)T45G多态性.方法 PCR-RFLP方法.结果白族 APM1 45位各基因型频率及等位基因频率对照组与T2DM组间无统计学差异;汉族T2DM组GG基因型频率高于对照组(P＜0.05).结论 APM1 T45G多态性与T2DM的相关性可能存在种族差异:白族人群可能不相关,汉族人群可能相关.
목적 검측운남대리지구백족여한족대조인군급2형당뇨병(T2DM)환자지련소기인(APM1)T45G다태성.방법 PCR-RFLP방법.결과 백족 APM1 45위각기인형빈솔급등위기인빈솔대조조여T2DM조간무통계학차이;한족T2DM조GG기인형빈솔고우대조조(P＜0.05).결론 APM1 T45G다태성여T2DM적상관성가능존재충족차이:백족인군가능불상관,한족인군가능상관.
Objective To study the correlation of T45G polymorphism of adiponectin gene(APM1)with type 2 diabetes mellitus (T2DM) in Bai and Han populations in Dali area. Methods The APM1 T45G polymorphism was detected by PCR-RFLP in nondiabetic controls and patients with T2DM. Results In Bai population,the frequencies of diversified genotypes and alleles of APM1 T45G had no significant difference between control group and T2DM group (all P>0.05). In Han population,the frequency of GG genotype was higher in T2DM group than in control group(10.5% vs 1.5%,P<0.05). Conclusions The correlation between APM1 T45G polymorphism and T2DM may have ethnic difference. In Bai nation,the polymorphism is not related to the occurrence of T2DM.The APM1 45 GG genotype may play a role in the occurrence of T2DM in Han populations