中国临床新医学
中國臨床新醫學
중국림상신의학
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
2009年
7期
691-693
,共3页
系统性红斑狼疮%骨髓%血细胞细胞减少%骨髓发育不良
繫統性紅斑狼瘡%骨髓%血細胞細胞減少%骨髓髮育不良
계통성홍반랑창%골수%혈세포세포감소%골수발육불량
Systemic lupus erythematosus%Bone marrow%Cytopenia%Dysplasias
目的 了解伴血细胞减少的系统性红斑狼疮(SLE)骨髓细胞形态学变化.方法 对34例外周血细胞减少的SLE患者(WBC<4×109/L, 或Hb<100 g/L, 或Pt<100×109/L)的骨髓涂片进行回顾性细胞形态学检查,并与26例特发性血小板减少性紫癜(ITP)、18例骨髓增生异常综合征的难治性贫血(MDS-RA)患者以及14例健康对照者综合分析.结果 34例SLE患者中24例(70.6%)骨髓发育不良,包括红系多核(三核或更多)10例(29.4%),巨幼样变8例(23.5%), Pelger-Hüet样畸形12例(35.3%),多核巨核细胞8例(23.5%),小型巨核细胞10例(29.4%). 结论在伴血细胞减少的SLE患者中能观察到骨髓多系细胞发育不良,这些改变说明骨髓可能是SLE侵犯的靶器官之一.
目的 瞭解伴血細胞減少的繫統性紅斑狼瘡(SLE)骨髓細胞形態學變化.方法 對34例外週血細胞減少的SLE患者(WBC<4×109/L, 或Hb<100 g/L, 或Pt<100×109/L)的骨髓塗片進行迴顧性細胞形態學檢查,併與26例特髮性血小闆減少性紫癜(ITP)、18例骨髓增生異常綜閤徵的難治性貧血(MDS-RA)患者以及14例健康對照者綜閤分析.結果 34例SLE患者中24例(70.6%)骨髓髮育不良,包括紅繫多覈(三覈或更多)10例(29.4%),巨幼樣變8例(23.5%), Pelger-Hüet樣畸形12例(35.3%),多覈巨覈細胞8例(23.5%),小型巨覈細胞10例(29.4%). 結論在伴血細胞減少的SLE患者中能觀察到骨髓多繫細胞髮育不良,這些改變說明骨髓可能是SLE侵犯的靶器官之一.
목적 료해반혈세포감소적계통성홍반랑창(SLE)골수세포형태학변화.방법 대34예외주혈세포감소적SLE환자(WBC<4×109/L, 혹Hb<100 g/L, 혹Pt<100×109/L)적골수도편진행회고성세포형태학검사,병여26례특발성혈소판감소성자전(ITP)、18례골수증생이상종합정적난치성빈혈(MDS-RA)환자이급14례건강대조자종합분석.결과 34례SLE환자중24례(70.6%)골수발육불량,포괄홍계다핵(삼핵혹경다)10례(29.4%),거유양변8례(23.5%), Pelger-Hüet양기형12례(35.3%),다핵거핵세포8례(23.5%),소형거핵세포10례(29.4%). 결론재반혈세포감소적SLE환자중능관찰도골수다계세포발육불량,저사개변설명골수가능시SLE침범적파기관지일.
Objective To 1earn bone marrow morphocytology in systemic lupus erythematosus(SLE) patients with peripheral cytopenia.Methods The smears of bone marrow aspirates obtained from 34 SLE patients who had bone marrow aspiration due to peripheral cytopenia (WBC<4×109/L, or Hb<100 g/L, or platelet count<100×109/L) were examined retrospectively.And the smears of the bone marrow aspirates obtained from 14 healthy controls,18 patients with MDS (refractory anemia), and 26 patients with idiopathic thrombocytopenic purpura (ITP) were inserted randomly among those obtained from the SLE patients.Results Of the 34 SLE patients, 24(70.6%) had dysplasias, including: erythroid cell multinuclearity (trinuclear or more) 10(29.4%), megaloblastoid changes 8(23.5%), pseudo Pelger-Hüet abnormalities 12(35.3%),separated nuclear megakaryocytes 8(23.5%), and micromegakaryocytes 10(29.4%).Conclusion This study found that bone marrow dysplasia can be observed in all lineage cells of SLE patients, We conclude that the bone marrow may be a target organ in SLE with cytopenia.
