天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2009年
12期
1004-1006
,共3页
超声心动描记术%多普勒%彩色%先兆子%脐动脉%血流速度%一氧化氮%预后
超聲心動描記術%多普勒%綵色%先兆子%臍動脈%血流速度%一氧化氮%預後
초성심동묘기술%다보륵%채색%선조자%제동맥%혈류속도%일양화담%예후
echocardiography%doppler%color preeclampsia umbilical arteries blood flow velocity nitric oxide prognosis
目的:探讨子前期(preeclempcia,PE)患者脐动脉血流与脐静脉血清sEng、一氧化氮(NO)水平及其围产儿预后的关系. 方法:对39例PE患者(轻度PE 20例,重度PE 19例)、20例妊娠期高血压患者及20例正常足月妊娠者采用彩色超声多普勒进行胎儿脐动脉阻力指数(RI)、搏动指数(PI)、收缩期峰值流速(Vs)、舒张末期及收缩期峰值流速与舒张末期流速比值(S/D)值测量,采用酶联免疫吸附法(ELISA)检测各组脐静脉血清sEng水平,用硝酸还原法测定各组脐静脉血清NO水平,分析其与围产儿预后的关系.结果:与正常妊娠组及妊娠期高血压组相比,轻、重度PE组的S/D、RI、PI、sEng水平明显升高,Vs、Vd及NO水平明显下降(均P < 0.05);轻、重度PE组PI、RI、S/D与sEng水平呈正相关,与NO水平呈负相关(均P < 0.05);PE患者围产儿病率明显增加(均P < 0.05).在PE患者中,与围产儿预后良好组相比, 围产儿预后不良组的PI、 RI、 S/D及sEng明显增高, Vs、 Vd及NO水平明显下降(均P < 0.05).结论:脐动脉血流参数可以客观反映病情及胎儿的宫内状态,具有重要的临床价值.
目的:探討子前期(preeclempcia,PE)患者臍動脈血流與臍靜脈血清sEng、一氧化氮(NO)水平及其圍產兒預後的關繫. 方法:對39例PE患者(輕度PE 20例,重度PE 19例)、20例妊娠期高血壓患者及20例正常足月妊娠者採用綵色超聲多普勒進行胎兒臍動脈阻力指數(RI)、搏動指數(PI)、收縮期峰值流速(Vs)、舒張末期及收縮期峰值流速與舒張末期流速比值(S/D)值測量,採用酶聯免疫吸附法(ELISA)檢測各組臍靜脈血清sEng水平,用硝痠還原法測定各組臍靜脈血清NO水平,分析其與圍產兒預後的關繫.結果:與正常妊娠組及妊娠期高血壓組相比,輕、重度PE組的S/D、RI、PI、sEng水平明顯升高,Vs、Vd及NO水平明顯下降(均P < 0.05);輕、重度PE組PI、RI、S/D與sEng水平呈正相關,與NO水平呈負相關(均P < 0.05);PE患者圍產兒病率明顯增加(均P < 0.05).在PE患者中,與圍產兒預後良好組相比, 圍產兒預後不良組的PI、 RI、 S/D及sEng明顯增高, Vs、 Vd及NO水平明顯下降(均P < 0.05).結論:臍動脈血流參數可以客觀反映病情及胎兒的宮內狀態,具有重要的臨床價值.
목적:탐토자전기(preeclempcia,PE)환자제동맥혈류여제정맥혈청sEng、일양화담(NO)수평급기위산인예후적관계. 방법:대39례PE환자(경도PE 20례,중도PE 19례)、20례임신기고혈압환자급20례정상족월임신자채용채색초성다보륵진행태인제동맥조력지수(RI)、박동지수(PI)、수축기봉치류속(Vs)、서장말기급수축기봉치류속여서장말기류속비치(S/D)치측량,채용매련면역흡부법(ELISA)검측각조제정맥혈청sEng수평,용초산환원법측정각조제정맥혈청NO수평,분석기여위산인예후적관계.결과:여정상임신조급임신기고혈압조상비,경、중도PE조적S/D、RI、PI、sEng수평명현승고,Vs、Vd급NO수평명현하강(균P < 0.05);경、중도PE조PI、RI、S/D여sEng수평정정상관,여NO수평정부상관(균P < 0.05);PE환자위산인병솔명현증가(균P < 0.05).재PE환자중,여위산인예후량호조상비, 위산인예후불량조적PI、 RI、 S/D급sEng명현증고, Vs、 Vd급NO수평명현하강(균P < 0.05).결론:제동맥혈류삼수가이객관반영병정급태인적궁내상태,구유중요적림상개치.
Objective: To explore the association of fetal umbilical artery (UA) Doppler blood flow parameters with umbilical vein (UV) serum sEng,nitric oxide (NO) level and the perinatal outcome in patients with preeclampsia(PE). Methods: Color ultrasonography was used to detect the resistive index (RI), pulse index (PI), the peak systolic velocity (Vs), diastolic velocity (Vd) and the peak-systolic/diastolic ratio(S/D) of UA in 39 PE patients(20 cases of mild preeclampsia, 19 cases of severe preeclampsia), 20 cases of normal full-term pregnant women and 20 gestational hypertension(GH) women. The UV serum level of sEng was analyzed using enzyme-linked immunosorbent assay (ELISA). The level of NO was determined using nitric acid recovery, and to analysis of perinatal outcome. Results: Compared with normal pregnancy and GH, levels of S/D, RI, PI and sEng were significantly higher in the mild and severe preeclampsia group(P < 0.05), and levels of Vs, Vd and NO were significantly lower(P < 0.05). There was a negative correlation between the values of PI, RI and S/D with the level of UV serum NO in the mild and severe preeclampsia group(P < 0.05). There was a positive correlation between the values of PI, RI and S/D with the level of UV serum sEng in the mild and severe PE group (P < 0.05). The incidence of perinatal disease was significantly higher in PE (P < 0.05). Compared with normal perinatal infants, the abnormal perinatal infants had obviously higher levels of S/D, RI, PI and sEng (P < 0.05), and lower levels of Vs, Vd and NO(P < 0.05) in PE. Conclusion: The umbilical artery blood flow parameters can reflect the disease condition and fetal status, which has an important clinical value.
