CAJ | 학술논문

目的:观察阿托伐他汀对急性脑出血患者血清II-lβ、TNF-α、和OX-LDL血脂的影响,探讨阿托伐他汀对急性脑出血脑保护作用.方法:60例脑出血患者分为4组:急性脑出血血脂正常组(A组)、急性脑出血高血脂组(AH组)、血脂正常急性脑出血阿托伐他汀治疗组(AT组)、高血脂急性脑出血阿托伐他汀治疗组(AHT组).神经功能缺损程度评分(Neurologicaldeftciency score,NDS)检测临床治疗效果.双抗体夹心ELISA法测定II-lβ、TNF-α和OX-LDL,生物化学法测定血脂.结果:AT组血清II-lβ、TNF-α、OX-LDL浓度和A组比较显著降低(P<0.05),经过阿托伐他汀治疗2,4、6周后lI-lβ、TNF-α、OX-LDL浓度值和治疗前比较无明显变化(p>0.05).AHT组血清II-lβ、TNF-α、OX-LDL浓度和AH组比较显著降低(P<0.01),经过阿托伐他汀治疗4周、6周后IL-lβ、TNF-α、OX-LDL浓度值和治疗2周值比较明显降低(p<0.01).结论:阿托伐他汀能够降低急性脑出血患者血清II-lβ、TNF-α、OX-LDL水平,阿托伐他汀对急性脑出血可以通过抑制炎症反应和氧化应激发挥治疗保护作用.
목적:관찰아탁벌타정대급성뇌출혈환자혈청II-lβ、TNF-α、화OX-LDL혈지적영향,탐토아탁벌타정대급성뇌출혈뇌보호작용.방법:60례뇌출혈환자분위4조:급성뇌출혈혈지정상조(A조)、급성뇌출혈고혈지조(AH조)、혈지정상급성뇌출혈아탁벌타정치료조(AT조)、고혈지급성뇌출혈아탁벌타정치료조(AHT조).신경공능결손정도평분(Neurologicaldeftciency score,NDS)검측림상치료효과.쌍항체협심ELISA법측정II-lβ、TNF-α화OX-LDL,생물화학법측정혈지.결과:AT조혈청II-lβ、TNF-α、OX-LDL농도화A조비교현저강저(P<0.05),경과아탁벌타정치료2,4、6주후lI-lβ、TNF-α、OX-LDL농도치화치료전비교무명현변화(p>0.05).AHT조혈청II-lβ、TNF-α、OX-LDL농도화AH조비교현저강저(P<0.01),경과아탁벌타정치료4주、6주후IL-lβ、TNF-α、OX-LDL농도치화치료2주치비교명현강저(p<0.01).결론:아탁벌타정능구강저급성뇌출혈환자혈청II-lβ、TNF-α、OX-LDL수평,아탁벌타정대급성뇌출혈가이통과억제염증반응화양화응격발휘치료보호작용.
Objective: To observe the influence of atorvastatin on serum levels of IL-lβ,TNF_α,OX-LDL and serum lipid in cerebral spontaneous hemorrhage to study its protection mechanisms for cerebral spontaneous hemorrhage.Methods: Sixty patients with cerebral hemorrhage were divided into normal serum lipid level group with cerebral spontaneous hemorrhage(A),and higher serum lipid level group with cerebral spontaneous hemorrhage (AH),normal serum lipid level cerebral spontaneous hemorrhage group with atorvastatin treatment(AT),and higher serum lipid level cerebral spontaneous hemorrhage group with atorvastatin treatment(AHT).Neurological deftciency score was examined. IL-lβ,TNF-α,and 0X-LDL were measured by enzyme linked immunosorbent assay;and serum lipid level was measured by biochemistry. Results: The serum levels of II-1β,TNF-α,and OX-LDL in AT group were significantly decreased compared with those of A group(P<0.05).At 2w,4w and 6w after treatment,the serum levels of IL-1β,TNF-α,and OX-LDL had no obvious change compared with those before treatment(P>0.05);The serum levels of lL-1β,TNF-α,and OX-LDL in AHT group were significantly lower than those in AH group,and compared with those at 2w,all the levels at 4w and 6w were significantly lower(P<0.01). Conclusion: Atorvastatin can decrease the serum levels of IL-1β,TNF-α,and OX-LDL and may have protecting functions on cerebral spontaneous hemorrhage by restraining inflammation and oxidative stress.