CAJ | 학술논문

肿瘤血管生成是恶性肿瘤快速增殖和转移的重要途径,多种细胞及分子因素参与肿瘤血管生成过程.血管生成素-2( Ang-2)是重要的血管内皮生长因子之一,主要通过松解血管结构、破坏血管稳定性而影响肿瘤血管生成.近年来研究证实Ang-2在肿瘤血管生成中与其他血管生长因子相互作用共同调节新生血管形成.随着研究的新进展,Ang-2不仅会成为抗肿瘤血管生成治疗的重要靶点,而且联合其他信号通路作为共同靶点将进一步提高临床抗肿瘤疗效.
종류혈관생성시악성종류쾌속증식화전이적중요도경,다충세포급분자인소삼여종류혈관생성과정.혈관생성소-2( Ang-2)시중요적혈관내피생장인자지일,주요통과송해혈관결구、파배혈관은정성이영향종류혈관생성.근년래연구증실Ang-2재종류혈관생성중여기타혈관생장인자상호작용공동조절신생혈관형성.수착연구적신진전,Ang-2불부회성위항종류혈관생성치료적중요파점,이차연합기타신호통로작위공동파점장진일보제고림상항종류료효.
Tumor angiogenesis is an important way of rapid proliferation and metastasis for malignancies,and a variety of cellular and molecular factors involved in the process.Angiopoietin-2(Ang-2) is one of the important vascular endothelial growth factor,which influences tumor angiogenesis mainly through releasing vascular structures and damaging the vessel stability.Recent researches reveal that Ang-2 modulates tumor angiogenesis interacting with other vascular growth factors.With the new research progress,Ang-2 will not only be an important target for antiangiogenic therapy,but also further improve clinical efficacy of antitumor therapy combined with other signal pathways as common targets.