CAJ | 학술논문

细胞凋亡为脑缺血时细胞死亡的重要形式之一.磷脂酰肌醇-3激酶(phosphoinositide-3 kinase,PI3K)/丝氨酸-苏氨酸蛋白激酶(serine/threonine kinase,Akt)为重要的细胞存活信号通路,c-Jun氨基端激酶(c-jun N-terminal kinase,JNK)为重要的促进细胞凋亡信号通路.这两大通路转导信号的动态平衡维持着生理状态下的细胞生存与凋亡.脑缺血刺激打破了这一生理平衡,导致大量神经细胞凋亡.多种确切的神经保护因素都与增强细胞存活信号的放大或抑制凋亡信号的放大有关,从而维持这2个通路信号的平衡.
세포조망위뇌결혈시세포사망적중요형식지일.린지선기순-3격매(phosphoinositide-3 kinase,PI3K)/사안산-소안산단백격매(serine/threonine kinase,Akt)위중요적세포존활신호통로,c-Jun안기단격매(c-jun N-terminal kinase,JNK)위중요적촉진세포조망신호통로.저량대통로전도신호적동태평형유지착생리상태하적세포생존여조망.뇌결혈자격타파료저일생리평형,도치대량신경세포조망.다충학절적신경보호인소도여증강세포존활신호적방대혹억제조망신호적방대유관,종이유지저2개통로신호적평형.
Apoptosis is one of the important forms during cerebral ischemia.Phosphoinositide-3 kinase (PI3K)/serine/threonine kinase (Akt) is the important cell survival signaling pathway,while c-jun N-terminal kinase (JNK) is the important pro-apoptotic signaling pathway.The dynamic equilibrium of the two signal transduction pathways maintains cell survival and apoptosis under the physiological state.Stimulation during cerebral ischemia breaks this physiological balance and results in the apoptosis of massive neurons.A variety of proved neuroprotective factors are associated with the amplification of enhancement of cell survival signal or inhibition of apoptosis signal,and thrus maintain the balance between the two signal pathways.