国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2008年
6期
482-485
,共4页
曹雪梅%李武修%高玉光%唐胜建
曹雪梅%李武脩%高玉光%唐勝建
조설매%리무수%고옥광%당성건
转化生长因子-β%Smads蛋白%信号转导%转录调节因子
轉化生長因子-β%Smads蛋白%信號轉導%轉錄調節因子
전화생장인자-β%Smads단백%신호전도%전록조절인자
Transforming growth factor-β,Smads protein%Signal transduetion%Transcription regulation factors
转化生长因子-β(TGF-β)超家族在胚胎发育和细胞的分化中具有多方面的生理功能,调控基因十分广泛.Smads蛋白是TGF-β超家族表达细胞内重要的信号转导和调控分子.多种DNA结合蛋白可以与Smads结合,直接影响其所调控基因的差异.Smads蛋白在DNA共结合因子辅助下,招募转录激活因子或转录抑制因子调控靶基因的转录.
轉化生長因子-β(TGF-β)超傢族在胚胎髮育和細胞的分化中具有多方麵的生理功能,調控基因十分廣汎.Smads蛋白是TGF-β超傢族錶達細胞內重要的信號轉導和調控分子.多種DNA結閤蛋白可以與Smads結閤,直接影響其所調控基因的差異.Smads蛋白在DNA共結閤因子輔助下,招募轉錄激活因子或轉錄抑製因子調控靶基因的轉錄.
전화생장인자-β(TGF-β)초가족재배태발육화세포적분화중구유다방면적생리공능,조공기인십분엄범.Smads단백시TGF-β초가족표체세포내중요적신호전도화조공분자.다충DNA결합단백가이여Smads결합,직접영향기소조공기인적차이.Smads단백재DNA공결합인자보조하,초모전록격활인자혹전록억제인자조공파기인적전록.
Transforming growth factor-β(TGF-β)superfamily have versatile physiological functions in the embryonic development and cell differentiation,and can widely regulate gene expressions.Smads protein is a important molecule of signal transduction and regulation in the TGF-β superfamily expression cells.Several DNA binding proteins can bind to Smads,which directly impact their differences of regulating gene.Smads protein is under the assistance of DNA binding factor,recruiting activating transcription factors or transcription inhibition factors to regulating transduetion of target gene.
