中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2009年
1期
37-38
,共2页
肺透明膜病%血气分析%纤维蛋白原%D-二聚体
肺透明膜病%血氣分析%纖維蛋白原%D-二聚體
폐투명막병%혈기분석%섬유단백원%D-이취체
Hyaline membrane disease%Blood gas analysis%Fibrinogen%D-dimmer
目的 探讨重症新生儿肺透明膜病(NHMD)患儿血气及纤维蛋白原(FBG)、D-二聚体(D-D)的变化及相关性.方法 43例重症NHMD患儿(需机械通气治疗)、26例轻症NHMD患儿(无需机械通气治疗)作为观察组,31例早产儿作为对照组,均测定血气、FBG和D-D水平.结果 重症NHMD患儿血pH值、动脉氧分压、FBG降低,动脉二氧化碳分压、D-D升高,与另两组比较,差异有非常显著性(P<0.01).重症NHMD患儿血pH值与血浆D-D呈负相关(r=-0.62,P<0.01),而与血浆FBG呈正相关(r=0.57,P<0.01).结论 重症NHMD患儿存在凝血功能异常,低氧血症、酸中毒与其密切相关.
目的 探討重癥新生兒肺透明膜病(NHMD)患兒血氣及纖維蛋白原(FBG)、D-二聚體(D-D)的變化及相關性.方法 43例重癥NHMD患兒(需機械通氣治療)、26例輕癥NHMD患兒(無需機械通氣治療)作為觀察組,31例早產兒作為對照組,均測定血氣、FBG和D-D水平.結果 重癥NHMD患兒血pH值、動脈氧分壓、FBG降低,動脈二氧化碳分壓、D-D升高,與另兩組比較,差異有非常顯著性(P<0.01).重癥NHMD患兒血pH值與血漿D-D呈負相關(r=-0.62,P<0.01),而與血漿FBG呈正相關(r=0.57,P<0.01).結論 重癥NHMD患兒存在凝血功能異常,低氧血癥、痠中毒與其密切相關.
목적 탐토중증신생인폐투명막병(NHMD)환인혈기급섬유단백원(FBG)、D-이취체(D-D)적변화급상관성.방법 43례중증NHMD환인(수궤계통기치료)、26례경증NHMD환인(무수궤계통기치료)작위관찰조,31례조산인작위대조조,균측정혈기、FBG화D-D수평.결과 중증NHMD환인혈pH치、동맥양분압、FBG강저,동맥이양화탄분압、D-D승고,여령량조비교,차이유비상현저성(P<0.01).중증NHMD환인혈pH치여혈장D-D정부상관(r=-0.62,P<0.01),이여혈장FBG정정상관(r=0.57,P<0.01).결론 중증NHMD환인존재응혈공능이상,저양혈증、산중독여기밀절상관.
Objective To explore the changes of blood gas, plasma fibrinogen and D-dimmer levels in neonates with severe hyaline membrane disease (HMD). Methods Forty - three neonates with severe HMD(treated by mechanical ventilation) ,26 neonates with mild HMD( without treated by mechanical venti-lation) and 31 controls were studied. The blood gas,plasma fibrinogen and D-dimmer levels were measured. Results Compared with other two groups, the levels of blood pH, PaO2 and FBG decreased significantly in neonates with severe HMD (P<0.01). The levels of PaCO2 and D-dimmer increased significantly (P<0.01). The blood pH was negatively correlated with plasma D-dimmer level,but it was positively correlated with plasma FBG level in neonates with severe HMD. Conclusion There are coagulation abnormalities in neonates with severe HMD. Hypoxemia and acidosis have close relationship with the coagulation abnormali-ties.
