CAJ | 학술논문

Wnt信号通路在骨骼发育中扮演重要角色,并通过多种途径影响骨肉瘤(OS)细胞株的增殖、凋亡和浸润转移.近年来,wnt信号通路在OS细胞株、OS模型和作为OS诊断和预后判定标志物作用的实验证据表明,Wnt信号通路在OS发生、进展和浸润转移中发挥关键作用,而且靶向Wnt通路治疗OS的策略及安令性评价也正在进行.探讨Wnt信号通路在OS发病、进展中的重要作用可能为OS的个性化治疗和提高患者生存率提供新的际遇.
Wnt신호통로재골격발육중분연중요각색,병통과다충도경영향골육류(OS)세포주적증식、조망화침윤전이.근년래,wnt신호통로재OS세포주、OS모형화작위OS진단화예후판정표지물작용적실험증거표명,Wnt신호통로재OS발생、진전화침윤전이중발휘관건작용,이차파향Wnt통로치료OS적책략급안령성평개야정재진행.탐토Wnt신호통로재OS발병、진전중적중요작용가능위OS적개성화치료화제고환자생존솔제공신적제우.
The Wnt pathway plays a crucial role in skeletal development and is indispensable for determination of OS cell lines. In recent years, experimental evidences on Wnt signaling pathway in OS cell lines and OS animal models, and that of Wnt signaling pathway as a diagnosis and prognosis marker of OS suggested that Wnt signaling pathway plays an important role in the progression, invasion and metastasis of OS. In addition, the strategy and safety evaluation to target Wnt to treat OS are underway. Exploring the significant role of Wnt signaling pathway in OS may aid in personalizing therapeutics to increase patient survival.