CAJ | 학술논문

目的通过比较慢性阻塞性肺疾病(COPD)患者、慢性中重度牙周炎患者和COPD合并中重度慢性牙周炎患者血清中白细胞介素19(IL-19)的含量,探讨中重度慢性牙周炎和COPD之间可能存在的关系.方法选取临床确诊的COPD患者51例,中重度慢性牙周炎患者61例,COPD合并中重度慢性牙周炎患者97例,健康成人22名共计4组.收集各组受试者静脉血清样本,采用酶联免疫吸附法测定血清IL-19水平.结果慢性中重度牙周炎患者血清IL-19含量(106.31±32.45)ng/L与非牙周炎患者血清IL-19(95.54±39.21)ng/L含量差异有统计学意义(P＜0.05),COPD患者血清IL-19含量(107.41±38.43)ng/L与非COPD患者(94.48±33.23)ng/L差异也有统计学意义(P＜0.05),但析因设计方差分析发现在慢性牙周炎与COPD之间的交互作用P＞0.05,即不能认为两者之间存在交互影响.结论血清中IL-19的表达可能与COPD及中重度慢性牙周炎发病机制有关.
목적 통과비교만성조새성폐질병(COPD)환자、만성중중도아주염환자화COPD합병중중도만성아주염환자혈청중백세포개소19(IL-19)적함량,탐토중중도만성아주염화COPD지간가능존재적관계.방법 선취림상학진적COPD환자51례,중중도만성아주염환자61례,COPD합병중중도만성아주염환자97례,건강성인22명공계4조.수집각조수시자정맥혈청양본,채용매련면역흡부법측정혈청IL-19수평.결과 만성중중도아주염환자혈청IL-19함량(106.31±32.45)ng/L여비아주염환자혈청IL-19(95.54±39.21)ng/L함량차이유통계학의의(P＜0.05),COPD환자혈청IL-19함량(107.41±38.43)ng/L여비COPD환자(94.48±33.23)ng/L차이야유통계학의의(P＜0.05),단석인설계방차분석발현재만성아주염여COPD지간적교호작용P＞0.05,즉불능인위량자지간존재교호영향.결론 혈청중IL-19적표체가능여COPD급중중도만성아주염발병궤제유관.
Objective Periodontitis is an inflammatory disease which may be associated with chronic obstructive pulmonary disease (COPD). Interleukin-19 (IL-19) might be involved in the common inflammatory mechanisms. This study investigated the association of serum levels of IL-19 with periodontitis and COPD in a Chinese population. Methods Fifty-one patients with chronic obstructive pulmonary disease, sixty-one patients with periodontitis, ninety-seven patients with both COPD and periodontitis and twenty-two healthy people were included in the study. The blood serum IL-19 levels was detected by ABC-ELISA. Results The differences in IL-19 expression were significant both between periodontitis group and non-periodontitis group, COPD group and non-COPD group (P ＜ 0.05). However, there was no interaction detected between the two diseases on IL-19 expression. Conclusion Serum IL-19 level increases in both periodontitis patients and COPD patientsand IL-19 might be associated with the pathogenesis of periodontitis and COPD.