CAJ | 학술논문

目的回顾分析口腔黏膜下纤维性变(oral submucous fibrosis,OSF)癌变的临床特点、病理以及生物学行为特性,为其临床治疗提供理论依据和指导.方法对经手术治疗的528例口腔黏膜鳞状细胞癌患者临床资料进行回顾性分析,将其分为OSF癌变组(133例)及非OSF癌变组(395例).对两组年龄、性别、发病部位、病理学分型、淋巴结转移率及术后复发率等进行比较分析.结果 OSF癌变组患者平均年龄(45.7±8.1)岁,低于非OSF癌变组(55.8±11.3)岁;OSF癌变组男女之比为32.3:1,高于非OSF癌变组(2.3:1);OSF癌变组淋巴转移率13.5%(18/133)、复发率39.1%(52/133),均高于非OSF癌变组[7.6%(30/395)、27.8%(110/395)].结论 OSF癌变平均发病年龄提前,男性居多,在临床上更具侵袭性和转移性的生物学行为,预后较差,在临床上应引起高度重视.
목적 회고분석구강점막하섬유성변(oral submucous fibrosis,OSF)암변적림상특점、병리이급생물학행위특성,위기림상치료제공이론의거화지도.방법 대경수술치료적528례구강점막린상세포암환자림상자료진행회고성분석,장기분위OSF암변조(133례)급비OSF암변조(395례).대량조년령、성별、발병부위、병이학분형、림파결전이솔급술후복발솔등진행비교분석.결과 OSF암변조환자평균년령(45.7±8.1)세,저우비OSF암변조(55.8±11.3)세;OSF암변조남녀지비위32.3:1,고우비OSF암변조(2.3:1);OSF암변조림파전이솔13.5%(18/133)、복발솔39.1%(52/133),균고우비OSF암변조[7.6%(30/395)、27.8%(110/395)].결론 OSF암변평균발병년령제전,남성거다,재림상상경구침습성화전이성적생물학행위,예후교차,재림상상응인기고도중시.
Objective To investigate the clinical characteristics,pathological and biological behaviors of oral squamous cell carcinomas(OSCC) originated from oral submucous fibrosis(OSF). Methods A total of 528 patients with OSCC treated at Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University from 2002 to 2010 were divided into two groups, OSCC originated from OSF and OSCC not originated from OSF. The clinical data regarding age, gender, location, pathological type, metastasis and recurrence rate of these patients were analyzed retrospectively. ResultsThe mean age of the group of OSCC originated from OSF (45.8 years) was younger than that of the group of OSCC not originated from OSF(55.9 years). The and recurrence rate of the group of OSCC originated from OSF(13.5%, 39.1%)was higher than that of the group of OSCC not originated from OSF(7.6%, 27.8%.). Conclusions OSCC originated from OSF occurs at younger age and more in male, and is clinically more invasive and metastatic.