中华医学遗传学杂志
中華醫學遺傳學雜誌
중화의학유전학잡지
CHINESE JOURNAL OF MEDICAL GENETICS
2012年
3期
255-259
,共5页
向波%吴俊瑶%马小红%王英成%邓伟%陈壮飞%李名立%王强%何宗岭%蒋丽君%李涛
嚮波%吳俊瑤%馬小紅%王英成%鄧偉%陳壯飛%李名立%王彊%何宗嶺%蔣麗君%李濤
향파%오준요%마소홍%왕영성%산위%진장비%리명립%왕강%하종령%장려군%리도
精神分裂症%全基因组关联分析%记忆功能%数量性状
精神分裂癥%全基因組關聯分析%記憶功能%數量性狀
정신분렬증%전기인조관련분석%기억공능%수량성상
Schizophrenia%Genome-wide association study%Memory cognition%Quantitative trait
目的 用全基因组关联研究分析精神分裂症患者和对照组基因多态性位点与记忆功能的相关性,从而找出精神分裂症相关的基因位点.方法 对98例首发精神分裂症患者和60名正常对照采用HumanHap660 Bead Array芯片进行基因分型,共有464 301个SNPs符合质量控制标准.以SNPs为分析因素,年龄、性别和受教育年限为协变量,瞬时记忆、延时记忆为数量性状,用PLINK软件分别对患病组和正常组进行主效应分析.结果 5个易感基因,包括RASGRF2(rs401758,P=8.03×10-5)、PLCG2(rs7185362,p=4.54×10-5)、LMOI (rs484161,P=9.80×10-7)、CSMDl (rs2469383;P=2.77×10-6)以及PRKG1(rs7898516,P=6.94×i0-5)可能与记忆功能障碍有关.结论 5个基因可能与精神分裂症的记忆功能缺陷相关.这些基因在精神分裂症的记忆功能以及神经系统发育中所起重要的作用可为下一步研究提供重要的线索.
目的 用全基因組關聯研究分析精神分裂癥患者和對照組基因多態性位點與記憶功能的相關性,從而找齣精神分裂癥相關的基因位點.方法 對98例首髮精神分裂癥患者和60名正常對照採用HumanHap660 Bead Array芯片進行基因分型,共有464 301箇SNPs符閤質量控製標準.以SNPs為分析因素,年齡、性彆和受教育年限為協變量,瞬時記憶、延時記憶為數量性狀,用PLINK軟件分彆對患病組和正常組進行主效應分析.結果 5箇易感基因,包括RASGRF2(rs401758,P=8.03×10-5)、PLCG2(rs7185362,p=4.54×10-5)、LMOI (rs484161,P=9.80×10-7)、CSMDl (rs2469383;P=2.77×10-6)以及PRKG1(rs7898516,P=6.94×i0-5)可能與記憶功能障礙有關.結論 5箇基因可能與精神分裂癥的記憶功能缺陷相關.這些基因在精神分裂癥的記憶功能以及神經繫統髮育中所起重要的作用可為下一步研究提供重要的線索.
목적 용전기인조관련연구분석정신분렬증환자화대조조기인다태성위점여기억공능적상관성,종이조출정신분렬증상관적기인위점.방법 대98례수발정신분렬증환자화60명정상대조채용HumanHap660 Bead Array심편진행기인분형,공유464 301개SNPs부합질량공제표준.이SNPs위분석인소,년령、성별화수교육년한위협변량,순시기억、연시기억위수량성상,용PLINK연건분별대환병조화정상조진행주효응분석.결과 5개역감기인,포괄RASGRF2(rs401758,P=8.03×10-5)、PLCG2(rs7185362,p=4.54×10-5)、LMOI (rs484161,P=9.80×10-7)、CSMDl (rs2469383;P=2.77×10-6)이급PRKG1(rs7898516,P=6.94×i0-5)가능여기억공능장애유관.결론 5개기인가능여정신분렬증적기억공능결함상관.저사기인재정신분렬증적기억공능이급신경계통발육중소기중요적작용가위하일보연구제공중요적선색.
[Objective]To assess the association between gene polymorphisms and memory function through a genome-wide association study (GWAS) of schizophrenia and control group.Memory cognition was used as a quantitative trait (QT).[Methods] Ninty-eight subjects with chronic schizophrenia and 60 matched controls were genotyped with HumanHap660 Bead Array.The results were correlated with quantitative traits including memory and memory delay.[Results] Five candidate genes,includingRASGRF2 (rs401758,P=8.03× 10-5),PLCG2 (rs7185362,P=4.54×10-5),LMO1 (rs484161,P=9.80×10-7),CSMD1 (rs2469383,P=2.77×10-6) and PRKG1 (rs7898516,P =6.94×10-5) were associated with memory cognition deficits.[Conclusion] Using memory cognition as a quantitative trait,this Genome-wide association study has identified 5 susceptibility loci.With their association with nervous system development,neuronal growth,axon guidance and plasticity,brain development,above loci may play a role in the development of memory dysfunction in schizophrenia.
