CAJ | 학술논문

目的探讨葡萄糖转运蛋白1(GLUT-1)在卵巢浆液性肿瘤中的表达及其意义.方法收集100例卵巢浆液性肿瘤患者手术标本,采用多克隆抗体的GLUT-1免疫组织化学SP法进行染色,分析其异常表达与肿瘤临床分期及分型之间的相关性.结果正常组织中GLUT-1表达为阴性,GLUT-1在良性、交界性、恶性卵巢浆液性肿瘤中的表达呈增高趋势(P<0.001),GLUT-1的表达与卵巢浆液性囊腺癌临床分期呈正相关(P<0.001).结论 GLUT-1的过度表达与卵巢浆液性肿瘤的组织学和分期相关.GLUT-1有望成为检测卵巢浆液性肿瘤恶变的标志物.
목적 탐토포도당전운단백1(GLUT-1)재란소장액성종류중적표체급기의의.방법 수집100례란소장액성종류환자수술표본,채용다극륭항체적GLUT-1면역조직화학SP법진행염색,분석기이상표체여종류림상분기급분형지간적상관성.결과 정상조직중GLUT-1표체위음성,GLUT-1재량성、교계성、악성란소장액성종류중적표체정증고추세(P<0.001),GLUT-1적표체여란소장액성낭선암림상분기정정상관(P<0.001).결론 GLUT-1적과도표체여란소장액성종류적조직학화분기상관.GLUT-1유망성위검측란소장액성종류악변적표지물.
Objective To evaluate the expression of the GLUT-1 glucose transporter in borderline and malignant epithelial neoplasms of the ovary. Methods Histologic sections of tumor tissues from 100 epithelial neoplasms of the ovary were stained for GLUT-1 using polyclonal GLUT-1 antibody and the labeled streptavidin procedure. Chi-square analysis was used to assess if their expression was associated with clinicopathoiogic characteristics of the tumors. Results Normal ovarian surface epithelial cell were either negative or weakly positive. The intensity of the stain was significantly stronger in malignant than borderline tumors (P<0.001). In malignant neoplasms, the intensity of the stain for GLUT-1 increased with histology. Conclusion Overexpression of the GLUT-1 transporter is associated with the histology and grade of the minors. These data suggest that the expression of this transporter may be closely related to the malignant transformation of epithelial ovarian tumors.