CAJ | 학술논문

目的探讨经颅微电流刺激( TES)治疗广泛性焦虑症患者的疗效.方法将广泛性焦虑症患者62例分为治疗组32例与对照组30例.治疗组采用TES治疗加文拉法辛治疗,对照组单独用文拉法辛治疗.TES治疗每天1次,疗程2周；文拉法辛每天75 ～ 150 mg,疗程4周.于治疗前及治疗第1、2、4周末采用汉密尔顿焦虑量表(HAMA)对2组患者进行评定.结果治疗前2组HAMA总评分、精神性焦虑与躯体性焦虑因子评分比较差异均无统计学意义(P＞0.05)；治疗第1周末,2组的HAMA总评分、精神性焦虑与躯体性焦虑因子评分与组内治疗前比较,差异无统计学意义(P＞0.05)；治疗第2,4周末,2组的HAMA总评分、精神性焦虑与躯体性焦虑因子评分与组内治疗前比较,差异均有统计学意义(P＜0.05)；2组在治疗第1、2、4周末HAMA总评分、精神性焦虑因子分与躯体性焦虑因子分总的平均变化差异无统计学意义(P＞0.05)；治疗第1周末,2组HAMA总评分及精神性焦虑因子评分的有效率比较,治疗组优于对照组(P＜0.05),而治疗第2、4周末,2组HAMA总评分及精神性焦虑因子评分的有效率差异无统计学意义(P＞0.05)；治疗第1、2、4周末2组躯体性焦虑因子评分的有效率差异无统计学意义(P＞0.05).结论 TES辅助文拉法辛治疗可较快改善广泛性焦虑症患者的焦虑症状.
목적 탐토경로미전류자격( TES)치료엄범성초필증환자적료효.방법 장엄범성초필증환자62례분위치료조32례여대조조30례.치료조채용TES치료가문랍법신치료,대조조단독용문랍법신치료.TES치료매천1차,료정2주；문랍법신매천75 ～ 150 mg,료정4주.우치료전급치료제1、2、4주말채용한밀이돈초필량표(HAMA)대2조환자진행평정.결과 치료전2조HAMA총평분、정신성초필여구체성초필인자평분비교차이균무통계학의의(P＞0.05)；치료제1주말,2조적HAMA총평분、정신성초필여구체성초필인자평분여조내치료전비교,차이무통계학의의(P＞0.05)；치료제2,4주말,2조적HAMA총평분、정신성초필여구체성초필인자평분여조내치료전비교,차이균유통계학의의(P＜0.05)；2조재치료제1、2、4주말HAMA총평분、정신성초필인자분여구체성초필인자분총적평균변화차이무통계학의의(P＞0.05)；치료제1주말,2조HAMA총평분급정신성초필인자평분적유효솔비교,치료조우우대조조(P＜0.05),이치료제2、4주말,2조HAMA총평분급정신성초필인자평분적유효솔차이무통계학의의(P＞0.05)；치료제1、2、4주말2조구체성초필인자평분적유효솔차이무통계학의의(P＞0.05).결론 TES보조문랍법신치료가교쾌개선엄범성초필증환자적초필증상.
Objective To investigate the effects of transcranial electrotherapy stimulation (TES)on patients with generalized anxiety disorder (GAD). Methods A total of 62 patients with GAD were randomly divided into two groups,the study group (treated with TES and venlafaxine) and the control group (treated with venlafaxine only).TES was administered 1 time per day for 14 days,while venlafaxine was administered with oral intake of 75-150mg/d for 4 weeks.The clinical effects were assessed by using Hamilton anxiety scale (HAMA). Results There was no difference between the two groups in average HAMA total scores,psychic and somatic factor scores before the treatments (P ＞ 0.05).The effective rate of study group was significantly higher ( P ＜ 0.05 ) at the end of the 1 st week after treatment than,but similar at the end of the 2nd and 4th week after treatment (P ＞ 0.05 ) to that,of control group,with regard to HAMA total score and psychic factor score.With regard to the HAMA somatic factor score,the effective rate of study group was not significantly different from that of control group at the end of the 1st,2nd and 4th week after treatment (P ＞ 0.05). Conclusion Transcranial electric stimulation in conjunction with venlafaxine may improve the symptoms of anxiety of patients.