CAJ | 학술논문

目的了解是否有足够的证据表明高压氧治疗糖尿病性周围神经病有效.方法电子检索PubMed、The Cochrane Central Register of Controlled Trails、EMbase、Science Citation Index Expanded、中国生物医学文献数据库(CBMDisc)、中国妇网(CNKI)、维普数据库(VIP),文献检索起止时间均为从建库到2010年7月,同时检索纳入文献的参考文献,纳入高压氧治疗糖尿病性周围神经病的随机对照试验,采用Cochrane协作网推荐的工具进行质量评价及资料提取.统计学分析采用RevMan 5.0.22.0软件.结果共检索到基本符合要求的随机对照试验7个,446例病例.所有研究认为高压氧治疗糖尿病性周围神经病有效.结论虽然现有证据提示高压氧治疗糖尿病性周围神经病变有效,但是缺乏设计严格的随机对照试验(RCT),所有研究都未说明随机的具体方法,是否实施分配隐藏,是否进行育法评价.研究质量有待改进,结果说服力不强,尚需高质量的RCT证实其疗效.
목적 료해시부유족구적증거표명고압양치료당뇨병성주위신경병유효.방법 전자검색PubMed、The Cochrane Central Register of Controlled Trails、EMbase、Science Citation Index Expanded、중국생물의학문헌수거고(CBMDisc)、중국부망(CNKI)、유보수거고(VIP),문헌검색기지시간균위종건고도2010년7월,동시검색납입문헌적삼고문헌,납입고압양치료당뇨병성주위신경병적수궤대조시험,채용Cochrane협작망추천적공구진행질량평개급자료제취.통계학분석채용RevMan 5.0.22.0연건.결과 공검색도기본부합요구적수궤대조시험7개,446례병례.소유연구인위고압양치료당뇨병성주위신경병유효.결론 수연현유증거제시고압양치료당뇨병성주위신경병변유효,단시결핍설계엄격적수궤대조시험(RCT),소유연구도미설명수궤적구체방법,시부실시분배은장,시부진행육법평개.연구질량유대개진,결과설복력불강,상수고질량적RCT증실기료효.
Objective To explore whether there is enough clinical evidence to confirm that hyperbaric oxygen (HBO) does more good than other treatments in treating patients with diabetic peripheral neuropathy. Methods Published clinical trials on hyperbaric oxygen treatment for diabetic peripheral neuropathy were collected through electronic searches of PubMed, the Cochrane Central Register of Controlled Trials, EMbase, Science Citation Index Expanded, the China Biological Medicine Database (CBM-disc), the Chinese National Knowledge Infrastructure (CNKI) and the VIP Database for Chinese Technical Periodicals (from the date of establishment of the databases to July 2010). The bibliographies of the retrieved articles were also checked. Results A total of 7 trials involving 446 patients with diabetic peripheral neuropathy were included. All studies reported positive results regarding the effects,but the quality of the studies was generally poor. The main problem was that most trials were reported as randomized and controlled, but with no description of the methods of randomization, concealment and blinding. Conclusions HBO in the treatment of diabetic peripheral neuropathy is promising based on present evidence. However at present,definite conclusions cannot be drawn about whether hyperbaric oxygen treatment is superior to the alternatives for patients with diabetic peripheral neuropathy. Higher quality randomized and controlled trials are required.