中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2010年
8期
114-115
,共2页
全反式维甲酸%三氧化二砷%急性早幼粒细胞白血病
全反式維甲痠%三氧化二砷%急性早幼粒細胞白血病
전반식유갑산%삼양화이신%급성조유립세포백혈병
Retinoic acid%Arsenic trioxide%Leukemia%Promyelocytic%Acute
目的 观察全反式维甲酸(ATRA)联合三氧化二砷(As2O3)治疗急性早幼粒细胞白血病(A PL)的疗效和不良反应.方法 ATRA联合As2O3治疗初治APL患者38例.给予全反式维甲酸(AT-RA)25 mg/(m2·d),分2～3次口服,三氧化二砷(As2O3)0.16 mg/(kg·d)静脉滴注.根据外周血白细胞数量、不良反应等调整用量.结果 34例完全缓解(CR),2例死亡.完全缓解(CR)率为89.5%,取得CR所需时间为(24.4士5.2)d.2例出现不良反应均经对症治疗好转.结论 ATRA联合As2O3治疗APL疗效好,不良反应少,达CR时间短.
目的 觀察全反式維甲痠(ATRA)聯閤三氧化二砷(As2O3)治療急性早幼粒細胞白血病(A PL)的療效和不良反應.方法 ATRA聯閤As2O3治療初治APL患者38例.給予全反式維甲痠(AT-RA)25 mg/(m2·d),分2～3次口服,三氧化二砷(As2O3)0.16 mg/(kg·d)靜脈滴註.根據外週血白細胞數量、不良反應等調整用量.結果 34例完全緩解(CR),2例死亡.完全緩解(CR)率為89.5%,取得CR所需時間為(24.4士5.2)d.2例齣現不良反應均經對癥治療好轉.結論 ATRA聯閤As2O3治療APL療效好,不良反應少,達CR時間短.
목적 관찰전반식유갑산(ATRA)연합삼양화이신(As2O3)치료급성조유립세포백혈병(A PL)적료효화불량반응.방법 ATRA연합As2O3치료초치APL환자38례.급여전반식유갑산(AT-RA)25 mg/(m2·d),분2～3차구복,삼양화이신(As2O3)0.16 mg/(kg·d)정맥적주.근거외주혈백세포수량、불량반응등조정용량.결과 34례완전완해(CR),2례사망.완전완해(CR)솔위89.5%,취득CR소수시간위(24.4사5.2)d.2례출현불량반응균경대증치료호전.결론 ATRA연합As2O3치료APL료효호,불량반응소,체CR시간단.
Objective To observe the eficacy and side efect of the all-trans retinoic acid (ATRA)and arsenic trioxide(As2O3)combination in acute promyeloeytic leukemia (APL). Methods Thirty-eight APL pa tients were treated with the ATRA and As2O3 combination. ATRA was given 25 mg/m2 every day and As2O3 was given 0. 16 mg/(kg · d). Doses were adjusted according to adverse effects. Results Thirty-four patients a chieved complete remission(CR) ,the CR rate was 89.5％. The time to achieve CR was(24. 4 ± 5.2)d. Two patients died due to intracranial hemorrhage. Conclusion The ATRA and As2O3 in the treatment of APL can obtain a higher CR rate and a shorter duration for achieving CR.
