国际护理学杂志
國際護理學雜誌
국제호이학잡지
INTERNATIONAL JOURNAL OF NURSING
2012年
9期
1592-1594
,共3页
膀胱灌注%吡柔比星%表浅性膀胱癌%复发
膀胱灌註%吡柔比星%錶淺性膀胱癌%複髮
방광관주%필유비성%표천성방광암%복발
Bladder irrigation%Pirarubicin%Superficial bladder cancer%Relapse
目的 观察不同保留时间膀胱灌注吡柔比星对预防表浅性膀胱癌术后复发的影响.方法 选择泌尿外科住院治疗的68例吡柔比星膀胱灌注治疗的表浅性膀胱癌术后患者为研究对象,随机将其分为对照组和观察组,于术后2周内开始吡柔比星膀胱灌注,每次灌注后妥善固定并保留气囊导尿再按规定变换体位,2组的保留灌注时间分别为15 min和30 min.20 mg/次,每周1次共8次,以后每个月1次共1年,观察2组患者的生存时间及复发情况.结果 观察组表浅性膀胱癌患者中位生存期为15个月,生存时间范围3 ～ 24个月.对照组表浅性膀胱癌患者中位生存期为11个月,生存时间范围3～ 24个月；对照组表浅性膀胱癌患者复发率(38.24％)明显高于观察组的(14.71％),2组表浅性膀胱癌患者复发率差异有统计学意义(x2=4.836,P=0.028).结论 吡柔比星膀胱内保留灌注30 min预防表浅性膀胱癌术后复发的疗效满意,复发率明显低于保留灌注15 min者,保留药物在膀胱内的同时保留导尿管的方法可保护尿道,避免化学性尿道炎的发生,值得推广运用.
目的 觀察不同保留時間膀胱灌註吡柔比星對預防錶淺性膀胱癌術後複髮的影響.方法 選擇泌尿外科住院治療的68例吡柔比星膀胱灌註治療的錶淺性膀胱癌術後患者為研究對象,隨機將其分為對照組和觀察組,于術後2週內開始吡柔比星膀胱灌註,每次灌註後妥善固定併保留氣囊導尿再按規定變換體位,2組的保留灌註時間分彆為15 min和30 min.20 mg/次,每週1次共8次,以後每箇月1次共1年,觀察2組患者的生存時間及複髮情況.結果 觀察組錶淺性膀胱癌患者中位生存期為15箇月,生存時間範圍3 ～ 24箇月.對照組錶淺性膀胱癌患者中位生存期為11箇月,生存時間範圍3～ 24箇月；對照組錶淺性膀胱癌患者複髮率(38.24％)明顯高于觀察組的(14.71％),2組錶淺性膀胱癌患者複髮率差異有統計學意義(x2=4.836,P=0.028).結論 吡柔比星膀胱內保留灌註30 min預防錶淺性膀胱癌術後複髮的療效滿意,複髮率明顯低于保留灌註15 min者,保留藥物在膀胱內的同時保留導尿管的方法可保護尿道,避免化學性尿道炎的髮生,值得推廣運用.
목적 관찰불동보류시간방광관주필유비성대예방표천성방광암술후복발적영향.방법 선택비뇨외과주원치료적68례필유비성방광관주치료적표천성방광암술후환자위연구대상,수궤장기분위대조조화관찰조,우술후2주내개시필유비성방광관주,매차관주후타선고정병보류기낭도뇨재안규정변환체위,2조적보류관주시간분별위15 min화30 min.20 mg/차,매주1차공8차,이후매개월1차공1년,관찰2조환자적생존시간급복발정황.결과 관찰조표천성방광암환자중위생존기위15개월,생존시간범위3 ～ 24개월.대조조표천성방광암환자중위생존기위11개월,생존시간범위3～ 24개월；대조조표천성방광암환자복발솔(38.24％)명현고우관찰조적(14.71％),2조표천성방광암환자복발솔차이유통계학의의(x2=4.836,P=0.028).결론 필유비성방광내보류관주30 min예방표천성방광암술후복발적료효만의,복발솔명현저우보류관주15 min자,보류약물재방광내적동시보류도뇨관적방법가보호뇨도,피면화학성뇨도염적발생,치득추엄운용.
Objective To investigate the influence on preventing the relapse of bladder cancer by pirarubicin irrigation ot bladder with different retaining time.Methods Sixty - eight cases of post - operative bladder superficial cancer irrigated with pirarubicin were selected.and divided into two groups randomly.Two weeks after operation pirarubicin bladder irrigation began.After every irrigation a well stabilized indwelling air - bulb catheter was used and the patient's lying posture changed routinely.The pirarubicin retaining time of these two groups were 15 minutes and 30 minutes respectively.Every time 20 mg of pirarubicin were used.This was done once every week and lasted for eight weeks.After this the irrigation is done once every month,and continued for 1 year.The patients'survival time and relapse rate were observed and compared.Results The average survival time of the first group was 15 months,while that of control group was 11 months.The relapse rate of the control group was 38. 24％ and it was by far higher than that of the first group ( 14.71％ ).The difference was significant. Conclusions The prevention of post - operative bladder cancer relapse - by pirarubicin bladder irrigation with a retaining time of 30minutes is a very satisfactory method.The relapse rate is lower than that of only retaining 15 minutes.Use of an indwelling air - bulb catheter can protect the urethra from chemical injury.It is worthy widely spreading.
