CAJ | 학술논문

目的评价高强度聚焦超声(HIFU)治疗晚期胰腺癌的作用、安全性和有效性.方法分析了128例晚期胰腺癌患者(Ⅲ期41例,Ⅳ期87例)接受HIFU治疗,通过临床症状、实验室检查、影像学变化和生存期等观察疗效.结果全组病例未发生严重不良反应,22.9％患者癌抗原19-9下降,疼痛缓解,有效率为72.5％.局灶近期疗效为部分缓解11.7％,稳定70.3％,进展18.0％.1年生存率为16.7％,中位生存期为7.0个月.其中Ⅲ期患者1年生存率为28.5％,中位生存期为9.0个月；Ⅳ期患者1年生存率为10.8％,中位生存期为6.0个月.结论 HIFU治疗能够有效稳定瘤灶、缓解疼痛、延长患者生存期且不良反应少,显示了良好的临床价值.
목적 평개고강도취초초성(HIFU)치료만기이선암적작용、안전성화유효성.방법 분석료128례만기이선암환자(Ⅲ기41례,Ⅳ기87례)접수HIFU치료,통과림상증상、실험실검사、영상학변화화생존기등관찰료효.결과 전조병례미발생엄중불량반응,22.9％환자암항원19-9하강,동통완해,유효솔위72.5％.국조근기료효위부분완해11.7％,은정70.3％,진전18.0％.1년생존솔위16.7％,중위생존기위7.0개월.기중Ⅲ기환자1년생존솔위28.5％,중위생존기위9.0개월；Ⅳ기환자1년생존솔위10.8％,중위생존기위6.0개월.결론 HIFU치료능구유효은정류조、완해동통、연장환자생존기차불량반응소,현시료량호적림상개치.
Objective To evaluate the analgesic efficacy and effect of high intensity focused ultrasound (HIFU) in the treatment of advanced pancreatic cancer.Methods 128 patients with pancreatic cancer ( Ⅲ stage 41 case,Ⅳ stage 87 case) were treated by HIFU.According to some parameters,such as the clinical symptoms,imaging examinations and survival analysis to assess the efficacy of HIFU treatment.Results 22.9％ patients’ serum Ca19-9 decreased.The cancer pain was relieved in 72.5％ patients.Coagulated-necrosis by CT/MRI examination was observed.PR,SD and PD of all were 11.7％,70.3％ and 18.0％ respectively.1-year survival rate was 16.7％ for all patients,and median survival time was 7.0 months.1-year survival rate and median survival time for Ⅲ stage group were 28.5％ and 9.0 months,that of 10.8％ and 6.0 months for Ⅳ stage group respectively.Conclusion HIFU may benefit to advanced pancreatic cancer patient by stabilizing tumors,relieving pain and prolonging life expectancy with less side effects.