中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2008年
6期
4-7
,共4页
吴永廉%张声%王国荣%陈余朋
吳永廉%張聲%王國榮%陳餘朋
오영렴%장성%왕국영%진여붕
胃癌%Claudin-1%表达转化%侵袭转移%免疫组化
胃癌%Claudin-1%錶達轉化%侵襲轉移%免疫組化
위암%Claudin-1%표체전화%침습전이%면역조화
Gastric carcinoma%Claudin-1%Expression transformation%Invasiveness and metastasis%Immunohistochemistry
目的 研究胃癌组织Clandin-1表达转化与胃癌侵袭转移的关系.方法 应用免疫组织化学检测136例胃癌黏膜层区、侵袭前沿区Claudin-1的表达.结果 胃癌黏膜层区,Claudin-1高表达率与腺癌的分化程度负相关,而与侵袭转移正相关.胃癌的侵袭前沿区,Claudin-1的高表达率与腺癌的分化程度呈正相关.随着肿瘤进展claudin-1的表达发生转变,即从低表达向高表达转化.胃癌侵袭越深Claudin-1从低表达向高表达转化率越高.有淋巴结转移者的Claudin-1从低表达向高表达转化率明显高于无淋巴结转移者.结论 claudin-1表达上调以及在胃癌侵袭过程中表达转化提示参与肿瘤的生物学行为的转化,但其确切机制以及与肿瘤进展间的关系需深入研究.
目的 研究胃癌組織Clandin-1錶達轉化與胃癌侵襲轉移的關繫.方法 應用免疫組織化學檢測136例胃癌黏膜層區、侵襲前沿區Claudin-1的錶達.結果 胃癌黏膜層區,Claudin-1高錶達率與腺癌的分化程度負相關,而與侵襲轉移正相關.胃癌的侵襲前沿區,Claudin-1的高錶達率與腺癌的分化程度呈正相關.隨著腫瘤進展claudin-1的錶達髮生轉變,即從低錶達嚮高錶達轉化.胃癌侵襲越深Claudin-1從低錶達嚮高錶達轉化率越高.有淋巴結轉移者的Claudin-1從低錶達嚮高錶達轉化率明顯高于無淋巴結轉移者.結論 claudin-1錶達上調以及在胃癌侵襲過程中錶達轉化提示參與腫瘤的生物學行為的轉化,但其確切機製以及與腫瘤進展間的關繫需深入研究.
목적 연구위암조직Clandin-1표체전화여위암침습전이적관계.방법 응용면역조직화학검측136례위암점막층구、침습전연구Claudin-1적표체.결과 위암점막층구,Claudin-1고표체솔여선암적분화정도부상관,이여침습전이정상관.위암적침습전연구,Claudin-1적고표체솔여선암적분화정도정정상관.수착종류진전claudin-1적표체발생전변,즉종저표체향고표체전화.위암침습월심Claudin-1종저표체향고표체전화솔월고.유림파결전이자적Claudin-1종저표체향고표체전화솔명현고우무림파결전이자.결론 claudin-1표체상조이급재위암침습과정중표체전화제시삼여종류적생물학행위적전화,단기학절궤제이급여종류진전간적관계수심입연구.
Objective To investigate the relationship of the expression transformation of claudin-1 with the invasiveness and metastasis in the gastric carcinoma. Methods By using the immunohistochemistry, the expression of claudin-1 in areas of mueosa and invasive front of 136 gastric adeocarcinomas. Results In the areas of mucosa, it is found that the relationship of the claudin-1 high-expression rate with the degree of differentiation is negative,however, the its relationship with invasiveness and metastasis is positive in the gastric carcinoma. In the areas of the invasive front, the relationship of the claudin-1 high-expression rate with the differentiation and invasiveness and metastasis of the gastric carcinoma is posive, in which the expression of claudin-1 transformed from low to high. The deeper the invasiveness, the higher the transformation. The claudin-1 expression transformation rate in the patients with metastasis was higher than those with not metastasis. Conclusion The up-regulation of claudin-1 expression and the expression transformation with the invasiveness and metastasis in the gastric carcinoma suggested that the claudin-1 participated in the transformation of biological behaviour in neoplasms, however, the precise mechanism and the relationship of the claudin-1 expression with the neoplasm progress need further study.
