中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
2期
155-156
,共2页
婴儿痉挛%托吡酯%多药联合%临床观察
嬰兒痙攣%託吡酯%多藥聯閤%臨床觀察
영인경련%탁필지%다약연합%림상관찰
Infantile spasms%Topiramate%Muti-medicine%Clinical investigation
目的 研究托吡酯等多药联合治疗婴儿痉挛症的临床疗效.方法 选择婴儿痉挛症患者134例,随机分为对照组和治疗组.对照组采用常规丙戊酸钠口服治疗;治疗组采用托吡酯、小剂量促肾上腺皮质激素(ACTH)+泼尼松、维生素B6、丙种球蛋白联合治疗.两组均连续治疗3个月后比较两组的脑电图改善情况和治疗效果.结果 治疗组临床疗效及脑电图改善情况均显著优于对照组(均P＜0.05).结论 托吡酯、小剂量ACTH+泼尼松、维生素B6、丙种球蛋白联合治疗婴儿痉挛症临床效果显著,优于单用丙戊酸钠治疗.
目的 研究託吡酯等多藥聯閤治療嬰兒痙攣癥的臨床療效.方法 選擇嬰兒痙攣癥患者134例,隨機分為對照組和治療組.對照組採用常規丙戊痠鈉口服治療;治療組採用託吡酯、小劑量促腎上腺皮質激素(ACTH)+潑尼鬆、維生素B6、丙種毬蛋白聯閤治療.兩組均連續治療3箇月後比較兩組的腦電圖改善情況和治療效果.結果 治療組臨床療效及腦電圖改善情況均顯著優于對照組(均P＜0.05).結論 託吡酯、小劑量ACTH+潑尼鬆、維生素B6、丙種毬蛋白聯閤治療嬰兒痙攣癥臨床效果顯著,優于單用丙戊痠鈉治療.
목적 연구탁필지등다약연합치료영인경련증적림상료효.방법 선택영인경련증환자134례,수궤분위대조조화치료조.대조조채용상규병무산납구복치료;치료조채용탁필지、소제량촉신상선피질격소(ACTH)+발니송、유생소B6、병충구단백연합치료.량조균련속치료3개월후비교량조적뇌전도개선정황화치료효과.결과 치료조림상료효급뇌전도개선정황균현저우우대조조(균P＜0.05).결론 탁필지、소제량ACTH+발니송、유생소B6、병충구단백연합치료영인경련증림상효과현저,우우단용병무산납치료.
Objective To observe the clinical effects of topiramate together with low-dose ACTH and prednisone、vitamine B6、gamma globulin on infantile spasms. Methods 134 infantile spasms patients were selected and randomly divided into control group and treatment group, each group 67 patients. The control group was treated with sodium valproate. The treatment group received low-dose ACTH and prednisone、topiramate、vitamine B6 、gamma globulin. The two groups all completed a therapeutic period of 3 months. Results The effect of the treatment group compared with the control group has significantly statistical difference (P ＜ 0.05) ;the result of the treatment group'electroencephalogran compared with that of the control group also has significants difference (P ＜ 0.05). Conclusion The therapeutic effect of low-dose ACTH and prednisone、 topiramate、 vitamine B6、 gamma globulin together on infantile spasms was much better than just taking sodium valproate only.
