中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2009年
2期
233-234
,共2页
胃肿瘤%多西紫杉醇%奥沙利铂
胃腫瘤%多西紫杉醇%奧沙利鉑
위종류%다서자삼순%오사리박
Stomach neoplasms%Docetaxel%Oxaliplatin
目的 评估多西紫杉醇联合奥沙利铂治疗进展期胃癌的效果和安全性.方法 130例进展期胃癌患者随机分为实验组87例,对照组43例,实验组给予多西紫杉醇50 mg/m2静脉滴注,第1~3天;奥沙利铂65 mg/m2静脉滴注,第1天;氟脲嘧啶(5-Fu)500 mg/m2静脉滴注,第1~5天;亚叶酸钙(CF)300 mg,第1~5天,在5-Fu之前2 h静脉滴注.对照组用奥沙利铂130 mg/m2静脉滴注,第1天;5-Fu与CF的给药方法同实验组.3周为1个周期,治疗2个周期后评价疗效.结果 实验组近期疗效、组织学变化、影像学变化等与对照组比较,差异均有统计学意义(均P<0.05).两组在白细胞减少、血小板减少、消化道反应、肝肾功能损害等不良反应方面比较,差异无统计学意义(均P>0.05).结论 多西紫杉醇联合奥沙利铂化疗方案治疗进展期胃癌安全、有效.
目的 評估多西紫杉醇聯閤奧沙利鉑治療進展期胃癌的效果和安全性.方法 130例進展期胃癌患者隨機分為實驗組87例,對照組43例,實驗組給予多西紫杉醇50 mg/m2靜脈滴註,第1~3天;奧沙利鉑65 mg/m2靜脈滴註,第1天;氟脲嘧啶(5-Fu)500 mg/m2靜脈滴註,第1~5天;亞葉痠鈣(CF)300 mg,第1~5天,在5-Fu之前2 h靜脈滴註.對照組用奧沙利鉑130 mg/m2靜脈滴註,第1天;5-Fu與CF的給藥方法同實驗組.3週為1箇週期,治療2箇週期後評價療效.結果 實驗組近期療效、組織學變化、影像學變化等與對照組比較,差異均有統計學意義(均P<0.05).兩組在白細胞減少、血小闆減少、消化道反應、肝腎功能損害等不良反應方麵比較,差異無統計學意義(均P>0.05).結論 多西紫杉醇聯閤奧沙利鉑化療方案治療進展期胃癌安全、有效.
목적 평고다서자삼순연합오사리박치료진전기위암적효과화안전성.방법 130례진전기위암환자수궤분위실험조87례,대조조43례,실험조급여다서자삼순50 mg/m2정맥적주,제1~3천;오사리박65 mg/m2정맥적주,제1천;불뇨밀정(5-Fu)500 mg/m2정맥적주,제1~5천;아협산개(CF)300 mg,제1~5천,재5-Fu지전2 h정맥적주.대조조용오사리박130 mg/m2정맥적주,제1천;5-Fu여CF적급약방법동실험조.3주위1개주기,치료2개주기후평개료효.결과 실험조근기료효、조직학변화、영상학변화등여대조조비교,차이균유통계학의의(균P<0.05).량조재백세포감소、혈소판감소、소화도반응、간신공능손해등불량반응방면비교,차이무통계학의의(균P>0.05).결론 다서자삼순연합오사리박화료방안치료진전기위암안전、유효.
Objective To evaluate the effect and toxicity of docetaxel combined with oxaliplatin,leucovorin and 5-fluorouracil regimen for patients with advanced gastric cancer,and compare with non-docetaxel chemotherapy regimen.Methods 130 patients with advanced gastric cancer were randomly divided into treatment group 87 patients and control group 43 patients.The regimen of the treatment groups was docetoxel 50mg/m2,iv infusion from day 1 to 3 ;oxaliplatin 65mg/m2,iv infusion on day 1 ;leucovofin 300mg/m2,iv infusion for 2 hours followed by 5-fluorouracil 500mg/m2,iv infusion from day 1 to 5.The regimen of the control group was oxaliplatin 130mg/m2,iv infusion on day 1.The usage of leucovorin and 5-fluorouracil were similar to the treatment group.All patients were evaluated after 2cycles( every cycle lasted 3 weeks).Results The effective rate in treatment group and in control group had statistical significance(P < 0.05).The main to:deities were no statistical difference in two groups( P > 0.05).Conclusion Docetoxel combined with oxaliplatin,leueovorin and 5-fluorouracil regimen is safe,high response and well tolerable for advanced gastric cancer.