CAJ | 학술논문

托莫西丁作为治疗儿童多动症的第一个非刺激的ADHD治疗剂，其合成方法早有较多的报道。但是都避不开mitsunob reaction反应，在这一步反应中，辅助试剂多、反应不彻底导致反应终了时体系成分复杂；中间体需经过柱层析分离，所用的溶剂和硅胶量大，操作时间长。本文采用新的分离方法：直接用适量的溶剂溶解粗产品，与硅胶混合、剧烈搅拌片刻，过滤，浓缩滤液即可高效率地分离得到目标中间体。
탁막서정작위치료인동다동증적제일개비자격적ADHD치료제，기합성방법조유교다적보도。단시도피불개mitsunob reaction반응，재저일보반응중，보조시제다、반응불철저도치반응종료시체계성분복잡；중간체수경과주층석분리，소용적용제화규효량대，조작시간장。본문채용신적분리방법：직접용괄량적용제용해조산품，여규효혼합、극렬교반편각，과려，농축려액즉가고효솔지분리득도목표중간체。
Atomoxitine ,as the first un-inmulated therapeutic for ADHD, synthesizes about it have been re- ported. While all the ways to it must use a mitsunob reaction-this need more reagents, which produce more s in the reaction system. So to get our target compound, offten need silica gel column chromatography, but 4 that will need more solvents and more silica even more time. In this paper, We will report a new method to separate the target-to dissolve the crude prodetion in developing solvent and then distribute in silica gel with violent stilting, several minutes latter,filter and concentrate it to get target production. In this way, We can easily improve efficience and cost less energy.