CAJ | 학술논문

目的观察门冬胰岛素30（诺和锐30）注射液强化治疗Ⅱ型糖尿病的效果.方法Ⅱ型糖尿病患者86例,给予生活方式干预,包括健康教育,低热量、低脂肪饮食,中等体力活动,戒烟、限酒,血压高者给予降压等,血脂异常者给予调脂.治疗组给予诺和锐30注射液3餐前皮注（根据血糖监测结果调整胰岛素剂量）,对照组给予诺和灵30R笔芯,早、晚餐前30 min皮注.观察6个月,观察治疗前后患者的FBG、2hPBG、HbA1c及低血糖发生率的变化.结果Ⅱ型糖尿病患者用诺和锐30强化治疗后,FBG、2hPBG、HbA1c等指标均好于对照组,低血糖发生率较对照组减少,P〈0.01,经比较有统计学意义.结论对Ⅱ型糖尿病患者应用诺和锐30强化治疗,血糖平稳,低血糖发生率减低,疗效肯定.
목적관찰문동이도소30（낙화예30）주사액강화치료Ⅱ형당뇨병적효과.방법Ⅱ형당뇨병환자86례,급여생활방식간예,포괄건강교육,저열량、저지방음식,중등체력활동,계연、한주,혈압고자급여강압등,혈지이상자급여조지.치료조급여낙화예30주사액3찬전피주（근거혈당감측결과조정이도소제량）,대조조급여낙화령30R필심,조、만찬전30 min피주.관찰6개월,관찰치료전후환자적FBG、2hPBG、HbA1c급저혈당발생솔적변화.결과Ⅱ형당뇨병환자용낙화예30강화치료후,FBG、2hPBG、HbA1c등지표균호우대조조,저혈당발생솔교대조조감소,P〈0.01,경비교유통계학의의.결론대Ⅱ형당뇨병환자응용낙화예30강화치료,혈당평은,저혈당발생솔감저,료효긍정.
Objective To observe effect of insulin aspart 30（novorapid） injection intensive treatment on type Ⅱ diabetes.Method 86 patients with type Ⅱ diabetes were given the lifestyle interventions,including health education,low-calorie and low fat diet,moderate physical activity,giving up smoking and limiting alcohol.Meanwhile,the patients with hypertension and（or） dyslipidemia were given antihypertensive therapy and（or） regulation of blood lipid respectively.86 patients were randomly divided into two groups,the treatment group was administered novorapid 30 injection in subcutaneous injection before 3 meals（insulin dosage was adjusted based on blood glucose monitoring results）,and the control group was administered novolin 30 in subcutaneous injection before 30 minutes breakfast and dinner for six months.Fasting blood glucose（FBS）,2-hour postprandial blood glucose（2hPBG）,HbA1c and the incidence of hypoglycemia were monitored before and after the treatment.Results FBG,2hPBG,HbA1c in type Ⅱ diabetic patients treated with novorapid 30 were decreased more significantly compared with those of patients treated with novolin 30.The incidence of hypoglycemia was lower in the treatment group compared with that in the control group（P0.05）.Conclusion Patients with type Ⅱ diabetes given novorapid 30 intensive treatment showed a stable blood glucose and a reduced incidence of hypoglycemia.The novorapid 30 has a good therapeutic effect on type Ⅱ diabetes.