广东畜牧兽医科技
廣東畜牧獸醫科技
엄동축목수의과기
GUANDONG JOURNAL OF ANIMAL AND VETERINARY SCIENCE
2011年
4期
17-19
,共3页
饶文%曾东平%刘宇
饒文%曾東平%劉宇
요문%증동평%류우
溶葡萄球菌酶%子宫内膜炎%奶牛%治疗效果
溶葡萄毬菌酶%子宮內膜炎%奶牛%治療效果
용포도구균매%자궁내막염%내우%치료효과
Lysostaphin%Endometritis%Dairycows%Thempeuticaleffect
溶葡萄球菌酶是从Staphylococcus Simulans培养物中提取的一种肽链内切酶,在较低浓度下能迅速裂解葡萄球菌细胞壁而呈现较强的杀菌活性且不易产生耐药性。为探讨溶葡萄球菌酶在防治奶牛子宫内膜炎上的应用,本试验选择140头患子宫内膜炎的奶牛,通过子宫内灌注给药的方式,每次分别灌注400u、800u和1600u溶葡萄球菌酶,连续给药3次,并以1O%Y-霉素注射液为对照,进行临床治疗试验。结果显示,溶葡萄球菌酶高、中、低剂量的治愈率分别为90.0%、73.3%和36.7%,对照药物治愈率为70.0%;在繁殖性能方面,高、中剂量组的奶牛情期内受胎率和总受胎率等明显高于低剂量组。表明溶葡萄球菌酶是一种治疗奶牛子宫内膜炎效果良好的生物类药物。
溶葡萄毬菌酶是從Staphylococcus Simulans培養物中提取的一種肽鏈內切酶,在較低濃度下能迅速裂解葡萄毬菌細胞壁而呈現較彊的殺菌活性且不易產生耐藥性。為探討溶葡萄毬菌酶在防治奶牛子宮內膜炎上的應用,本試驗選擇140頭患子宮內膜炎的奶牛,通過子宮內灌註給藥的方式,每次分彆灌註400u、800u和1600u溶葡萄毬菌酶,連續給藥3次,併以1O%Y-黴素註射液為對照,進行臨床治療試驗。結果顯示,溶葡萄毬菌酶高、中、低劑量的治愈率分彆為90.0%、73.3%和36.7%,對照藥物治愈率為70.0%;在繁殖性能方麵,高、中劑量組的奶牛情期內受胎率和總受胎率等明顯高于低劑量組。錶明溶葡萄毬菌酶是一種治療奶牛子宮內膜炎效果良好的生物類藥物。
용포도구균매시종Staphylococcus Simulans배양물중제취적일충태련내절매,재교저농도하능신속렬해포도구균세포벽이정현교강적살균활성차불역산생내약성。위탐토용포도구균매재방치내우자궁내막염상적응용,본시험선택140두환자궁내막염적내우,통과자궁내관주급약적방식,매차분별관주400u、800u화1600u용포도구균매,련속급약3차,병이1O%Y-매소주사액위대조,진행림상치료시험。결과현시,용포도구균매고、중、저제량적치유솔분별위90.0%、73.3%화36.7%,대조약물치유솔위70.0%;재번식성능방면,고、중제량조적내우정기내수태솔화총수태솔등명현고우저제량조。표명용포도구균매시일충치료내우자궁내막염효과량호적생물류약물。
Lysostaphin is a zinc-binding metalloenzyme first extracted from Staphylococcus simulans cultures. Lysostaphin acts as bactericidal antimicrobials by lysising taphylococcal cells at relatively low consentrations with good tolerance. 140 dairy cows suffered from endometritis were used for the study of lysostaphin on the therapy of endometritis in dairy cows by uterine infusion with 10% oxytetracycline as control. The recovery rates of experimental groups treated with 400, 800 and 1600U lysostaphin for 3 times were 90%, 73.3% and 36.7% respectively and the recovery rate was 70.0% in control group. Rates of pregnancy in estrus and total pregnancy of dairy cows treated with high and middle dosage were significantly higher than that of the group with 400U. It indicated that lysostaphin was a kind of biological drugs which could be used to treat cow endometritis efficiently.