中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2011年
2期
197-198
,共2页
急性ST段抬高心肌梗死%血清Ⅲ型前胶原氨基末端肽%心室重构
急性ST段抬高心肌梗死%血清Ⅲ型前膠原氨基末耑肽%心室重構
급성ST단태고심기경사%혈청Ⅲ형전효원안기말단태%심실중구
目的:观察急性ST段抬高心肌梗死(STEMI)患者血清Ⅲ型前胶原氨基端肽(PⅢNP)水平与心室重构和预后的关系.方法:100例STEMI患者入选,ELISA法测定入CCU即刻和发病第7天血清中PⅢNP含量.于发病第(7±2)天和6个月时行超声心动图检查,6个月复查超声ΔLVEDVI增加≥20%为重构组,ΔLVEDVI增加<20%为非重构组.结果:第7天时,STEMI患者血清PⅢNP浓度均明显高于入院水平[(7.95±3.61)ng/ml vs (4.18±1.83)ng/ml,P<0.001],急诊PCI患者血清PⅢNP浓度明显低于未行急诊PCI者[(7.02±2.97)ng/ml vs (11.07±3.82)ng/ml,P<0.001].6个月随访时左心室重构发生率为27.96%,急诊PCI患者22.78%,未急诊干预者57.14%,两组间有显著差异P=0.008.重构组患者第7天PⅢNP浓度明显高于非重构组[(10.82±3.91)ng/ml vs (6.86±2.83)ng/ml,P<0.001].结论:STEMI患者第7天血清PⅢNP水平与半年时心室重构的发生密切相关.第7天血清PⅢNP水平升高者心室重构率高,预后差.
目的:觀察急性ST段抬高心肌梗死(STEMI)患者血清Ⅲ型前膠原氨基耑肽(PⅢNP)水平與心室重構和預後的關繫.方法:100例STEMI患者入選,ELISA法測定入CCU即刻和髮病第7天血清中PⅢNP含量.于髮病第(7±2)天和6箇月時行超聲心動圖檢查,6箇月複查超聲ΔLVEDVI增加≥20%為重構組,ΔLVEDVI增加<20%為非重構組.結果:第7天時,STEMI患者血清PⅢNP濃度均明顯高于入院水平[(7.95±3.61)ng/ml vs (4.18±1.83)ng/ml,P<0.001],急診PCI患者血清PⅢNP濃度明顯低于未行急診PCI者[(7.02±2.97)ng/ml vs (11.07±3.82)ng/ml,P<0.001].6箇月隨訪時左心室重構髮生率為27.96%,急診PCI患者22.78%,未急診榦預者57.14%,兩組間有顯著差異P=0.008.重構組患者第7天PⅢNP濃度明顯高于非重構組[(10.82±3.91)ng/ml vs (6.86±2.83)ng/ml,P<0.001].結論:STEMI患者第7天血清PⅢNP水平與半年時心室重構的髮生密切相關.第7天血清PⅢNP水平升高者心室重構率高,預後差.
목적:관찰급성ST단태고심기경사(STEMI)환자혈청Ⅲ형전효원안기단태(PⅢNP)수평여심실중구화예후적관계.방법:100례STEMI환자입선,ELISA법측정입CCU즉각화발병제7천혈청중PⅢNP함량.우발병제(7±2)천화6개월시행초성심동도검사,6개월복사초성ΔLVEDVI증가≥20%위중구조,ΔLVEDVI증가<20%위비중구조.결과:제7천시,STEMI환자혈청PⅢNP농도균명현고우입원수평[(7.95±3.61)ng/ml vs (4.18±1.83)ng/ml,P<0.001],급진PCI환자혈청PⅢNP농도명현저우미행급진PCI자[(7.02±2.97)ng/ml vs (11.07±3.82)ng/ml,P<0.001].6개월수방시좌심실중구발생솔위27.96%,급진PCI환자22.78%,미급진간예자57.14%,량조간유현저차이P=0.008.중구조환자제7천PⅢNP농도명현고우비중구조[(10.82±3.91)ng/ml vs (6.86±2.83)ng/ml,P<0.001].결론:STEMI환자제7천혈청PⅢNP수평여반년시심실중구적발생밀절상관.제7천혈청PⅢNP수평승고자심실중구솔고,예후차.
