工业微生物
工業微生物
공업미생물
INDUSTRIAL MICROBIOLOGY
2009年
6期
49-54
,共6页
嗜热酶%结构特征%热稳定性
嗜熱酶%結構特徵%熱穩定性
기열매%결구특정%열은정성
thermozymes%structural features%thermostability
相对于嗜温酶,嗜热酶作为生物催化剂有许多优势而受到人们的广泛重视.嗜热酶的热稳定性机制历来是生物化学家们研究的重点.本文综述了嗜热酶的结构特征及其与热稳定性的关系.相对于嗜温酶,嗜热酶的结构比较僵硬,折叠紧密,α-螺旋更长,构象张力低,大多数为多聚体.了解嗜热酶的结构特征与热稳定性的关系,对于采用酶工程改造嗜温酶从而提高其热稳定性具有重要的指导意义.
相對于嗜溫酶,嗜熱酶作為生物催化劑有許多優勢而受到人們的廣汎重視.嗜熱酶的熱穩定性機製歷來是生物化學傢們研究的重點.本文綜述瞭嗜熱酶的結構特徵及其與熱穩定性的關繫.相對于嗜溫酶,嗜熱酶的結構比較僵硬,摺疊緊密,α-螺鏇更長,構象張力低,大多數為多聚體.瞭解嗜熱酶的結構特徵與熱穩定性的關繫,對于採用酶工程改造嗜溫酶從而提高其熱穩定性具有重要的指導意義.
상대우기온매,기열매작위생물최화제유허다우세이수도인문적엄범중시.기열매적열은정성궤제력래시생물화학가문연구적중점.본문종술료기열매적결구특정급기여열은정성적관계.상대우기온매,기열매적결구비교강경,절첩긴밀,α-라선경장,구상장력저,대다수위다취체.료해기열매적결구특정여열은정성적관계,대우채용매공정개조기온매종이제고기열은정성구유중요적지도의의.
More attentions are laid to thermozymes because of their advantages over the mesozymes.The thermostability mechanisms of thermozymes were studied extensively by biochemists.The relationships between structural features and thermostability of thermozymes were reviewed in this paper.Thermozymes are more rigid and compact than mesozymes.There are longer α-helix and less conformational strains in the thermozymes.Most of thermozymes are inclined to oligomerization as one of thermostability mechanisms.Understanding the relationships between structural features and thermostability of thermozymes will help to construct more useful enzymes by enzyme engineering.
