CAJ | 학술논문

mda-7/IL-24是20世纪90年代中期发现的一个新基因.由于mda-7/IL-24与人IL-10家族具有相当的同源性,后来HUGO基因命名委员会将之重新命名为IL-24,并将其归类到IL-10家族.近年研究表明,采用复制缺陷的腺病毒表达载体Ad.mda-7使其在肿瘤细胞异位表达,引起多种肿瘤细胞的生长抑制.尽管mda-7/IL-24肿瘤靶向性的作用机制还不是很清楚,但大量的实验结果表明该基因作为一个有效的肿瘤治疗基因,能够区分正常细胞和肿瘤细胞、诱导各种不同肿瘤细胞凋亡、启动抗肿瘤"旁观者效应"、增强肿瘤细胞对射线敏感性、抑制动物模型体内移植瘤的生长和血管新生以及具有调节免疫应答能力.
mda-7/IL-24시20세기90년대중기발현적일개신기인.유우mda-7/IL-24여인IL-10가족구유상당적동원성,후래HUGO기인명명위원회장지중신명명위IL-24,병장기귀류도IL-10가족.근년연구표명,채용복제결함적선병독표체재체Ad.mda-7사기재종류세포이위표체,인기다충종류세포적생장억제.진관mda-7/IL-24종류파향성적작용궤제환불시흔청초,단대량적실험결과표명해기인작위일개유효적종류치료기인,능구구분정상세포화종류세포、유도각충불동종류세포조망、계동항종류"방관자효응"、증강종류세포대사선민감성、억제동물모형체내이식류적생장화혈관신생이급구유조절면역응답능력.
The novel cytokine mda-7/IL-24 was identified by subtractive hybridization in the mid-1990s as a cytokine, which is highly expressed during the induction of terminal differentiation of melanoma, but not expressed or expressed at low levels in tumor cells compared to non-transformed cells. Based on its structure, chromosomal location, sequence homology and cytokine-like properties, mda-7 has now been renamed IL-24 and classified as a member of IL-10 cytokine gene family. Subsequently, several studies have demonstrated that ectopic expression of adenoviral mda-7 in tumor cells, including melanoma and carcinomas of lung, breast, prostate and cervix, inhibits tumor growth and ultimately cellular apoptosis. Although the mechanism of tumor-selectivity of mda-7/IL-24 remains to be elucidated, numerous attributes make this gene an effective anti-tumor therapy because of its multiple abilities for instance to discriminate normal and cancer cells, induce specific apoptosis of different cancer cells, promote "bystander" antitumor effects, inhibit tumor growth and angiogenesis in animal models, synergize with radiation, and modulate immune responses.