中国组织工程研究与临床康复
中國組織工程研究與臨床康複
중국조직공정연구여림상강복
JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH
2007年
43期
8816-8820
,共5页
卢智泉%王立华%贺振权%刘玉芳%张国毅%李志强%聂绍发
盧智泉%王立華%賀振權%劉玉芳%張國毅%李誌彊%聶紹髮
로지천%왕립화%하진권%류옥방%장국의%리지강%섭소발
良性前列腺增生%男性%吸烟%体质量指数%危险性
良性前列腺增生%男性%吸煙%體質量指數%危險性
량성전렬선증생%남성%흡연%체질량지수%위험성
背景:良性前列腺增生是一种老年男性常见的疾病,尽管发病的危险因素仍不清楚,但是诸多生活方式因素对此病具有一定的影响作用.目的:观察锦州地区男性吸烟、体质量指数与临床良性前列腺增生危险性之间的关系.设计:病例对照观察.单位:华中科技大学同济医学院流行病与统计学系;辽宁医学院预防医学教研室.对象:选择2004-05/2006-05在辽宁医学院附属第一及第三医院、锦州中心医院和锦州市第二人民医院泌尿外科收治的343例良性前列腺增生行外科手术患者为病例组,年龄50～82岁.纳入标准:①年龄＞50岁,I-PSS症状分＞7.②排尿后直肠指检前列腺Ⅰ度以上(横径＞3 cm).③B超检查示前列腺体积≥30 g.④最大尿流率＜15 mL/s;选择同期入住于上述医院,因患各种与良性前列腺增生、前列腺癌以及前列腺炎危险因素无关疾病的361例患者为对照组,年龄50～82岁,平均65岁.所有患者均对调查内容知情并同意.方法:采用标准调查表对病例组和对照组患者进行调查,定义一生总吸烟量≥20包为吸烟者,反之为不吸烟者.根据吸烟量分成不吸烟、吸烟量1～19支/d、吸烟量20～29支/d和吸烟量≥30支/d,并按吸烟的时间分为不吸烟、1～19年、20～29年和≥30年.通过询问法,获得受试对象体质量指数,分为体质量指数＜18.4、正常(体质量指数18.5～23.9)、超重(体质量指数24.0～27.9)和肥胖(体质量指数≥28);调查患者文化程度分为文化程度＜7年,7～11年和≥12年,患者的职业分为工人、农民、知识分子及其他.将调查结果输入计算机、建立数据库,应用多元Logistic模型分析患者吸烟量、吸烟时间、体质量指教、文化程度、职业与临床良性前列腺增生的比值比(OR)和95%可信限(Cl).主要观察指标:患者吸烟量、吸烟时间、体质量指数、文化程度、职业与临床良性前列腺增生的关系.结果:纳人病例组患者343例,对照组361例均进入结果分析.①吸烟量≥30支/d患者与不吸烟者相比,发生临床良性前列腺增生的危险性增加(OR=1.32,95%CL为0.92～2.58,P＜0.01).②超重及肥胖吸烟者发生临床良性前列腺增生的危险性较不吸烟者显著增高(OR=1.68,2.35,95%Cl分别为1.32～3.67,1.83～4.16,P＜(0.01).③体力劳动者(农民)与发生良性前列腺增生的危险性呈负相关(P＜0.05).脑力劳动者(知识分子)发生临床良性前列腺增生的危险性高于对照组(χ2=6.62,P＜0.01).结论:吸烟≥30支/d的男性与临床良性前列腺增生呈正相关,超重(体质量指数24.0～27.9)和肥胖(体质量指数≥28.0)的男性吸烟发生临床良性前列腺增生的危险性显著地升高.
揹景:良性前列腺增生是一種老年男性常見的疾病,儘管髮病的危險因素仍不清楚,但是諸多生活方式因素對此病具有一定的影響作用.目的:觀察錦州地區男性吸煙、體質量指數與臨床良性前列腺增生危險性之間的關繫.設計:病例對照觀察.單位:華中科技大學同濟醫學院流行病與統計學繫;遼寧醫學院預防醫學教研室.對象:選擇2004-05/2006-05在遼寧醫學院附屬第一及第三醫院、錦州中心醫院和錦州市第二人民醫院泌尿外科收治的343例良性前列腺增生行外科手術患者為病例組,年齡50～82歲.納入標準:①年齡＞50歲,I-PSS癥狀分＞7.②排尿後直腸指檢前列腺Ⅰ度以上(橫徑＞3 cm).③B超檢查示前列腺體積≥30 g.④最大尿流率＜15 mL/s;選擇同期入住于上述醫院,因患各種與良性前列腺增生、前列腺癌以及前列腺炎危險因素無關疾病的361例患者為對照組,年齡50～82歲,平均65歲.所有患者均對調查內容知情併同意.方法:採用標準調查錶對病例組和對照組患者進行調查,定義一生總吸煙量≥20包為吸煙者,反之為不吸煙者.根據吸煙量分成不吸煙、吸煙量1～19支/d、吸煙量20～29支/d和吸煙量≥30支/d,併按吸煙的時間分為不吸煙、1～19年、20～29年和≥30年.通過詢問法,穫得受試對象體質量指數,分為體質量指數＜18.4、正常(體質量指數18.5～23.9)、超重(體質量指數24.0～27.9)和肥胖(體質量指數≥28);調查患者文化程度分為文化程度＜7年,7～11年和≥12年,患者的職業分為工人、農民、知識分子及其他.將調查結果輸入計算機、建立數據庫,應用多元Logistic模型分析患者吸煙量、吸煙時間、體質量指教、文化程度、職業與臨床良性前列腺增生的比值比(OR)和95%可信限(Cl).主要觀察指標:患者吸煙量、吸煙時間、體質量指數、文化程度、職業與臨床良性前列腺增生的關繫.結果:納人病例組患者343例,對照組361例均進入結果分析.①吸煙量≥30支/d患者與不吸煙者相比,髮生臨床良性前列腺增生的危險性增加(OR=1.32,95%CL為0.92～2.58,P＜0.01).②超重及肥胖吸煙者髮生臨床良性前列腺增生的危險性較不吸煙者顯著增高(OR=1.68,2.35,95%Cl分彆為1.32～3.67,1.83～4.16,P＜(0.01).③體力勞動者(農民)與髮生良性前列腺增生的危險性呈負相關(P＜0.05).腦力勞動者(知識分子)髮生臨床良性前列腺增生的危險性高于對照組(χ2=6.62,P＜0.01).結論:吸煙≥30支/d的男性與臨床良性前列腺增生呈正相關,超重(體質量指數24.0～27.9)和肥胖(體質量指數≥28.0)的男性吸煙髮生臨床良性前列腺增生的危險性顯著地升高.
배경:량성전렬선증생시일충노년남성상견적질병,진관발병적위험인소잉불청초,단시제다생활방식인소대차병구유일정적영향작용.목적:관찰금주지구남성흡연、체질량지수여림상량성전렬선증생위험성지간적관계.설계:병례대조관찰.단위:화중과기대학동제의학원류행병여통계학계;료녕의학원예방의학교연실.대상:선택2004-05/2006-05재료녕의학원부속제일급제삼의원、금주중심의원화금주시제이인민의원비뇨외과수치적343례량성전렬선증생행외과수술환자위병례조,년령50～82세.납입표준:①년령＞50세,I-PSS증상분＞7.②배뇨후직장지검전렬선Ⅰ도이상(횡경＞3 cm).③B초검사시전렬선체적≥30 g.④최대뇨류솔＜15 mL/s;선택동기입주우상술의원,인환각충여량성전렬선증생、전렬선암이급전렬선염위험인소무관질병적361례환자위대조조,년령50～82세,평균65세.소유환자균대조사내용지정병동의.방법:채용표준조사표대병례조화대조조환자진행조사,정의일생총흡연량≥20포위흡연자,반지위불흡연자.근거흡연량분성불흡연、흡연량1～19지/d、흡연량20～29지/d화흡연량≥30지/d,병안흡연적시간분위불흡연、1～19년、20～29년화≥30년.통과순문법,획득수시대상체질량지수,분위체질량지수＜18.4、정상(체질량지수18.5～23.9)、초중(체질량지수24.0～27.9)화비반(체질량지수≥28);조사환자문화정도분위문화정도＜7년,7～11년화≥12년,환자적직업분위공인、농민、지식분자급기타.장조사결과수입계산궤、건립수거고,응용다원Logistic모형분석환자흡연량、흡연시간、체질량지교、문화정도、직업여림상량성전렬선증생적비치비(OR)화95%가신한(Cl).주요관찰지표:환자흡연량、흡연시간、체질량지수、문화정도、직업여림상량성전렬선증생적관계.결과:납인병례조환자343례,대조조361례균진입결과분석.①흡연량≥30지/d환자여불흡연자상비,발생림상량성전렬선증생적위험성증가(OR=1.32,95%CL위0.92～2.58,P＜0.01).②초중급비반흡연자발생림상량성전렬선증생적위험성교불흡연자현저증고(OR=1.68,2.35,95%Cl분별위1.32～3.67,1.83～4.16,P＜(0.01).③체력노동자(농민)여발생량성전렬선증생적위험성정부상관(P＜0.05).뇌력노동자(지식분자)발생림상량성전렬선증생적위험성고우대조조(χ2=6.62,P＜0.01).결론:흡연≥30지/d적남성여림상량성전렬선증생정정상관,초중(체질량지수24.0～27.9)화비반(체질량지수≥28.0)적남성흡연발생림상량성전렬선증생적위험성현저지승고.
BACKGROUND: Benign prostatic hyperplasia is a common disease of older males. Although the etiology remains unclear, the factors of life style and habits may have an effect on the disease.OBJECTIVE:To examine the association of cigarette smoking and body mass index with the risk of clinical benign prostatic hyperplasia.DESIGN: A hospital-based case-control study SETTINGS: Department of Epidemiology and Statistics, Public Health School,Tongji Medical College, Huazhong University of Science and Technology; Department of Preventive Medicine, Liaoning Medical College.PARTICIPANTS：Totally 343 males with benign prostatic hyperplasia of 50-82 years old (patient group),who were surgically treated between May 2004 and May 2006,were selected from the Department of Urinary Surgery of the First Affiliated Hospital and Third Affiliated Hospital of Liaoning Medical College (former Jinzhou Railway Central Hospital),Jinzhou Central Hospital and Jinzhou Second People's Hospital．Inclusive criteria：① males above 50 years old；intemational prostatic symptom score(IPSS)＞7；②Digital recta examination (DRE) after miction indicated prostate grade Ⅰ(transverse diameter＞3 cm); ③prostatic volume≥30 g; ④maximum unnary flow rate＜15 mL／s；Meanwhile，361 inpatients with diseases irrelative to the risk factors of benign prostatic hyperplasia,prostatic cancer and prostatitis were selected trom the above hospitals as the control group,they were 50-82 years of age with an average of 65 years old．Informed contents were obtained from all the enrolled subjects．METHODS：All the patients and controls were interviewed using an anonymous questionnaire．All participants were asked to report whether they had smoked 20 packs of cigarettes or more in their lifetimes and,if yes,they were smokers,on the contrary they were non-smokers． Based on usual number of cigarettes reported in the questionnaire, men were categorized as 1-10，11-20，21-30 and ＞30 cigarettes per day．Based on duration of smoking,the participants were funher classified as never smoke，1-19,20-29 and ≥30 years．Body mass index(BMI)was assessed from measured body mass and body height，and che standards of BMI in adults in China was 18．5-23．9 for normal,24．0-27．9 for overweight and ≥28．0 for obesity)，then the participants were further classified as BMI＜18．4，18．5-23．9,24．0-27．9 and ≥28．0 subgroups respectively．Years of education(＜7,7-11,and≥12) and occupation(worker,peasant,
Intellectual and others) were also investigated．The results of the investigation were input into computer to establish database，the odds ratios (OR) and the 95％ confidence interval(CI)in relation to the various measures were estimated using unconditional multiple logistic regression models, including number of cigarettes smoked per day， BMI, years smoked，years of education,occupation．MAIN OUTCOME MEASURES：Relationships of number of cigarettes smoked per day,years smoked．BMI,years of education and occupation with benign prostatic hyperplasia．RESULTS：Totally 343 cases in the patient group and 361 cases in the control group were involved in the analysis of results．①Patients smoked≥30 cigarettes per day had an elevated risk of benign prostatic hypertrophy as compared with the non-smokers(OR=1．32，95％ CI:0．92-2．58，P＜0．01)．②The risks of benign prostatic hypertrophy in overweight and obesity were significantly increased as compared with non-smokers(OR=1.68,95％ CI: 1．32-3．67；OR=2．35，95％CI:1．83-4．16)，③Manual worker (peasant) was negatively correlated with the risk of benign prostatic hyperplasia (χ2=6．62，P＜0．01)．CONCLUSION:Smoking 30 cigarettes per day was positively related to benign prostatic hyperplasia.For male who were
both overweight(BMI 24.0-27.9)and obesity(BMI≥28.0)，smoking was significantly associated the increased risk of surgically treated benign prostatic hyperplasia.
