CAJ | 학술논문

目的：研究三物降压汤对血压、淋巴因子激活的杀伤(LAK)细胞的影响及其可能机制。方法：用随机、单盲、自身、组间平行对照法用三物降压汤对轻度高血压病患者(n＝30)进行为期8周的治疗观察，并与开搏通治疗组(n＝30)比较。分别检测治疗前后的血压、LAK细胞的增殖与活性、LAK细胞表达的超氧化物歧化酶(SOD)样物质及其对自由基的清除能力，为进一步了解LAK细胞与血压之间的关系，并观察了自发性高血压大鼠(SHR)胸主动脉环对硝酸甘油和乙酰胆碱(Ach)的舒张反应以及LAK细胞与SOD标准品对SHR胸主动脉环对Ach舒张反应的影响并与京都威斯特大鼠及经三物降压汤治疗后的SHR比较。结果：三物降压汤在降血压同时，LAK细胞增殖、活性、其所表达的SOD及清除自由基效应均明显增加。结论：三物降压汤既能降血压又能调节免疫功能。
목적：연구삼물강압탕대혈압、림파인자격활적살상(LAK)세포적영향급기가능궤제。방법：용수궤、단맹、자신、조간평행대조법용삼물강압탕대경도고혈압병환자(n＝30)진행위기8주적치료관찰，병여개박통치료조(n＝30)비교。분별검측치료전후적혈압、LAK세포적증식여활성、LAK세포표체적초양화물기화매(SOD)양물질급기대자유기적청제능력，위진일보료해LAK세포여혈압지간적관계，병관찰료자발성고혈압대서(SHR)흉주동맥배대초산감유화을선담감(Ach)적서장반응이급LAK세포여SOD표준품대SHR흉주동맥배대Ach서장반응적영향병여경도위사특대서급경삼물강압탕치료후적SHR비교。결과：삼물강압탕재강혈압동시，LAK세포증식、활성、기소표체적SOD급청제자유기효응균명현증가。결론：삼물강압탕기능강혈압우능조절면역공능。
Objective: To investigate the effect of Sanwu hypotensivedecoction (SWHD) on blood pressure (BP) and lymphokine activated killer cell (LAK) and possible mechanism. Methods: Thirty mild hypertension patients were treated with SWHD for 8 weeks, the levels of BP, proliferative ability and activity of LAK cell, SOD-like substance expressed by LAK cell and its radical scavenger ability before and after treatment were observed using randomized, single blinded, self-control, paralled assay, and compared with other 30 patients treated with captopril for control. In an experimental study, the vasodilatory response of thoracic aortic ring to acetylcholine and nitroglycerine, and effect of LAK cell, standard reagent of SOD, SWHD on the response were observed and compared in spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKR). Results: After SWHD treatment, along with lowering of BP, the proliferative ability, activity SOD-like substance expressed by LAK cell and its radical scavenger ability increased significantly. Conclusion: SWHD is not only an effective hypotensive agent, but also an immunoregulator