CAJ | 학술논문

目的：观察原发性骨恶性淋巴瘤（PLB）的临床病理及免疫表型特征。方法：对8例PLB进行临床病理学观察及免疫组织化学染色(ABC法)。结果：8例PLB平均年龄51岁。X线片示溶骨性破坏或伴有骨质疏松；组织学观察均为弥漫性非霍奇金淋巴瘤（NHL），大细胞性4例、中心细胞性2例、混合细胞性（中心细胞-中心母细胞）和淋巴浆细胞样各1例；免疫组化显示B细胞6例、T细胞2例。结论：PLB好发于50岁左右，X线片主要表现为溶骨性破坏和骨质疏松。病理类型为弥漫性NHL，细胞形态主要是大细胞，免疫表型则以B细胞多见。免疫组化有助于PLB的鉴别诊断。
목적：관찰원발성골악성림파류（PLB）적림상병리급면역표형특정。방법：대8례PLB진행림상병이학관찰급면역조직화학염색(ABC법)。결과：8례PLB평균년령51세。X선편시용골성파배혹반유골질소송；조직학관찰균위미만성비곽기금림파류（NHL），대세포성4례、중심세포성2례、혼합세포성（중심세포-중심모세포）화림파장세포양각1례；면역조화현시B세포6례、T세포2례。결론：PLB호발우50세좌우，X선편주요표현위용골성파배화골질소송。병리류형위미만성NHL，세포형태주요시대세포，면역표형칙이B세포다견。면역조화유조우PLB적감별진단。
Purposes　To observe the clinicopathologic and immunohistochemical features of primary lymphoma of bone(PLB). Methods　Eight cases of PLB were investigated by light microscopy and immunohistochemical staining. Results　The mean age of eight cases of PLB was 51 years. Radiographs of all cases showed the lytic lesions or osteoporosises; All the cases were diffuse non-Hodgkins lymphomas(NHL), including 4 large cell lymphomas (centroblastic, CB), 2 centrocytic(CC), one mixed cell (CB-CC ) and one lymphoplasmacytic (LP); Immunohistochemical features revealed 6 cases of B-cell, 2 T-cell. Conclusions　The peak incidence for PLB is in the 5th decade with the radiologic appearance of lytic lesions or osteoporosises. All tumors are the diffuse NHL, including mainly large cell lymphomas and immunophenotypic features of B-cell lymphomas. Immunohistochemistry is helpful in the differential diagnosis of PLB.