CAJ | 학술논문

目的探讨急性脑梗死患者血清神经元特异性烯醇酶(NSE)的变化及其临床意义。方法采集69例脑梗死患者起病3天内的血标本，用酶联免疫分析法测定血清NSE含量（其中35例2周时复测）。结果脑梗死3天内血清NSE明显高于对照组及2周时（P<0.001）,血清NSE含量与梗死灶大小、神经功能缺损程度明显正相关（P<0.001），与意识障碍明显负相关（P< 0.001），临床疗效越差血清NSE含量越高（P<0.001）。结论脑梗死早期血清NSE明显升高，血清NSE含量与临床表现关系密切。
목적탐토급성뇌경사환자혈청신경원특이성희순매(NSE)적변화급기림상의의。방법채집69례뇌경사환자기병3천내적혈표본，용매련면역분석법측정혈청NSE함량（기중35례2주시복측）。결과뇌경사3천내혈청NSE명현고우대조조급2주시（P<0.001）,혈청NSE함량여경사조대소、신경공능결손정도명현정상관（P<0.001），여의식장애명현부상관（P< 0.001），림상료효월차혈청NSE함량월고（P<0.001）。결론뇌경사조기혈청NSE명현승고，혈청NSE함량여림상표현관계밀절。
Objective　To explore the change and clinical significance of serum neuron-specific enolase (NSE) in the patients with acute cerebral infarction.Methods　Blood samples(serum NSE levels) of 69 patients with cerebral infarction were determined by ELISA in the first 3 days,and 35 patients of them were determined again 2 weeks the onset.Results　NSE serum levels of patients were significantly higher in the first 3 days than in 2 weeks after the onset and the controls(P<0.001),there was a positive correlation between serum NSE levels and the volume of infraction, neurological deficit scores(P<0.001),and it was negative correlation with disorder of consciousness(P<0.001),the higher serum NSE levels indicated the worse clinical curative effect(P<0.001).Conclusion　Serum NSE levels were increased in the early stage of cerebral infarction, and there was a close relationship between NSE serum levels and clinical features.