CAJ | 학술논문

现已明确，心力衰竭时神经激素的持续剌激对心脏具有严重的损害作用。循环儿茶酚胺升高对心肌细胞产生直接的毒性作用、增加膜通透性和心肌纤维化，这些作用可引起细胞死亡。在心力衰竭治疗中常用的β受体阻滞剂包括：普萘洛尔、美托洛尔、比索洛尔、布新洛尔和卡维地洛。这些药物与血管紧张素转换酶抑制剂、洋地黄类和利尿剂联合应用。一般来说β受体阻滞剂治疗心力衰竭的益处有：改善症状，降低发病率、病死率，提高对住院的需要及生活质量。β受体阻滞剂能阻止和逆转左室重构，减少致死性心律失常和心源性猝死的危险。β受体阻滞剂的严重不良反应有低血压、心脏传导阻滞、心动过缓和液体潴留。现有大量资料证明β受体阻滞剂对心力衰竭治疗的有益作用，许多心脏病学者将其作为心力衰竭标准治疗的一个部分。
현이명학，심력쇠갈시신경격 소적지속랄격대심장구유엄중적손해작용。순배인다분알승고대심기세포산생직접적독성작 용、증가막통투성화심기섬유화，저사작용가인기세포사망。재심력쇠갈치료중상용적β수 체조체제포괄：보내락이、미탁락이、비색락이、포신락이화잡유지락。저사약물여혈관긴 장소전환매억제제、양지황류화이뇨제연합응용。일반래설β수체조체제치료심력쇠갈적익 처유：개선증상，강저발병솔、병사솔，제고대주원적수요급생활질량。β수체 조체제능조지화역전좌실중구，감소치사성심률실상화심원성졸사적위험。β수체조체제적 엄중불량반응유저혈압、심장전도조체、심동과완화액체저류。현유대량자료증명β수체조 체제대심력쇠갈치료적유익작용，허다심장병학자장기작위심력쇠갈표준치료적일개부분。
It is now clear that continued stimulation o f the neurohormonal system in heart failure (HF) has serious deleterious effects on the heart. The increase of circulating catecholamines exerts direct toxic ef fect on cardiac myocytes, increases membrane permeability and myocardial fibrosi s; lead to aggravation of HF. β-blockers are commonly used in the treatment of HF including propranolol, metoprolol, bisoprolol, bucindolol and carvedilol. These drugs are used in combination with ACEIs, digitalis and diuretics. Genera lly, the benefits of β-blockade therapy in HF include improving symptoms, decr easing morbidity, mortality, elevating need for hospitalization and quality of l ife. β- blockade therapy arrests and reverts LV remodeling and improves the ri sk of life threatening arrhythmias and sudden cardiac death. A few serious adver se effects include hypotension, heart blocks, bradycardia and fluid retention.