CAJ | 학술논문

目的：探讨强迫症患者事件相关电位P300 及其地形分布图特征。[ HT5”H〗方法：应用百胜伽利略REPORTER 型脑诱发电位仪对36例强迫症患者进行听觉事件相关电位P300 及其地形分布图检查。结果：与正常对照组(33人)相比，强迫症患者波形稳定差，23例(63.9％) 出现额叶波形变异或两侧不对称；N2、P3的潜伏期明显后移；波幅下降；36例患者的P3地形分布图均失正态分布，正常顶区高功率消失。左侧能量色差低于右侧3级以上的有19例(52.8％)，额叶能量差低于其它脑区3级以上的有10例(30.3％)。并发现临床上单纯强迫行为或强迫思维者多表现为顶叶处内源性成分能量缺乏；而一组病情较重的混合性患者或者伴有其他症状者多表现为顶叶伴额叶或左侧能量降低。结论：事件相关电位P300 及其地形分布图可作为研究强迫症患者认知功能的一项客观指标和重要辅助诊断。
목적：탐토강박증환자사건상관전위P300 급기지형분포도특정。[ HT5”H〗방법：응용백성가리략REPORTER 형뇌유발전위의대36례강박증환자진 행은각사건상관전위P300 급기지형분포도검사。결과：여정상대조 조(33인)상비，강박증환자파형은정차，23례(63.9％) 출현액협파형변이혹량측불대 칭；N2、P3적잠복기명현후이；파폭하강；36례환자적P3지형분포도균실정태분 포，정상정구고공솔소실。좌측능량색차저우우측3급이상적유19례(52.8％)，액협능량 차저우기타뇌구3급이상 적유10례(30.3％)。병발현림상 상단순강박행위혹강박사유자다표현위정협처내원성성분능량결핍；이일조병정교중적혼 합성환자혹자반유기타증상자다표현위정협반액협혹좌측능량강저。결론：사건상관전위P300 급기지형분포도가작위연구강박증환자인지공능적일항객관지표 화중요보조진단。
Objective: To study the characteristics of P300 and topographic dist ribution mapping in obsessive-compulsive patients. Methods: The P300 and topog raphic distribution mapping were recorded in 36 patients, using a Bneuro Galileoinstrument. Results: Compared with normal subjects, the wa ve patterns of obsessi ve-compulsive patients were unstable; the frontal wave variation and dissymmetry between the two sides was 63.9%; the N2 and P3 latency was prolonged; the P2 an d P3 amplitude was decreased; the P3 topographic distribution mapping was uneven ly distributed, the normal high amplitude in the parietal region was absent. For the patient group, energy levels below grade 5 in the left brain area, the fron tal area, and for both were 42.3%, 30.3%, 15.15% respectively. Conclu sion: P300 and topographic distribution might be served as an objective index for reflectin g cognitive activity in obsessive-compulsive patients.