CAJ | 학술논문

在信号转导过程中，可能存在有待发现的特异性信号转导分子，本文将简要探讨经Ca2+/Calcineurin与NF-AT转录复合物进行信号转导的特异性机制，及其在开发调节该信号转导途径的药物方面的潜在意义。本文例证给了我们一些有益的启示。
재신호전도과정중，가능존재유대발현적특이성신호전도분자， 본문장간요탐토경Ca2+/Calcineurin여NF-AT전록복합물진행신호전도적특이성궤제 ，급기재개발조절해신호전도도경적약물방면적잠재의의。본문예증급료아문일사유익적계 시。
Signal transduction was observed while activation of s pecific receptors leads to highly specific biologic responses, these receptors s eem to use ubiquitous signaling intermediates. One solution to this dilemma is t hat perhaps the specific signaling molecules are yet to be discovered. Recent re views have discussed the diverse roles of this ubiquitous signaling intermediate . The thesis will focus on recently discovered mechanisms that they are likely t o underlie the specificity of signaling through Ca2+/calcineurin and the N F-AT transcription complex and discuss the implication for the development of d rugs to modulate responses through this pathway.