CAJ | 학술논문

采用改良的冷冻融溶法制备氯氰碘柳胺脂质体，经线性试验、方法回收率、包封率测定和稳定性试验，该制剂符合质量标准。临床药物试验表明以2.5mg/kg的剂量皮下注射，对绵羊的肝片吸虫有完全的驱除作用，最佳使用剂量。该制剂用药量小，疗效高，毒副作用低，是一种值得推广的抗寄生虫药物。
채용개량적냉동융용법제비록청전류알지질체，경선성시험、방법회수솔、포봉솔측정화은정성시험，해제제부합질량표준。림상약물시험표명이2.5mg/kg적제량피하주사，대면양적간편흡충유완전적구제작용，최가사용제량。해제제용약량소，료효고，독부작용저，시일충치득추엄적항기생충약물。
Closantel-liposomes is produced with modified freeze-thawing method. This preparation is attested to be accord with quality standard after linear test, recovery test, encapsulated rate test and stability test. The result of clinical antiscolic test indicated, subcutaneously with the best dose of 2.5mg/kg b.w. closantel-liposomes, it has high helminthic efficacies on Fasciola hipatica in sheep. This preparation has many advantages, including low dosage, high effective, low side effect and safety. It is worth spreading in husbandry.