中国医学科学杂志(英文版)
中國醫學科學雜誌(英文版)
중국의학과학잡지(영문판)
CHINESE MEDICAL SCIENCES JOURNAL
2000年
4期
217-221
,共5页
王泽君%邓艳春%于德洁%鲍光宏
王澤君%鄧豔春%于德潔%鮑光宏
왕택군%산염춘%우덕길%포광굉
NO%ATP%free Ca2 +%Ca2 + store
Object. The effects of ATP-introduced a rise in cytosolic free Ca2 + concentration and inhibition of nitric oxide
were investigated.
Method. Measurement of f ree Ca2+ ([Ca2+ ]i)of cultured rat tail arterial smooth muscle cells using Fura-2/AM
dual excitation wavelength spoctrofluorometer.
Results. There are two components of [ Ca2 + ]i can be evoked by ATP. One part is Ca2 + ertry from Ca2 + channel
and formed a plateau. The another part is a peak that released f rom Ca2 + store. Both of them can be inhibited by NO.
Conclusion. The ATP induced [ Ga2 + ]i rise that release Ca2 + from both InsP3 and ryanochine receptors and Ga2 +
entry through calcium channels. The inhibition of NO on ATP induced [ Ca2 + ]i rise that was mediated by cGMP.
