清华大学学报(英文版)
清華大學學報(英文版)
청화대학학보(영문판)
TSINGHUA SCIENCE AND TECHNOLOGY
2002年
4期
404-406
,共3页
邓劲光%公衍道%程明愚%赵南明%张秀芳
鄧勁光%公衍道%程明愚%趙南明%張秀芳
산경광%공연도%정명우%조남명%장수방
chitosan%nerve conduit%alkylation%solubility
Chitosan under physiological conditions is a degradable and biocompatible biomaterial with a wide variety of useful physicochemical properties. However, as a nerve conduit biomaterial, its solubility was very low, so chitosan was modified chemically to enhance its solubility. The free amino groups of long molecular chains in chitosan are responsible for its solubility, and the solubility could be adjusted by controlling the free amidogen capacity with N-alkylation. The results show that the solubility of N-alkylation chitosan is increased to 10%, which is an increase of 500%.
