CAJ | 학술논문

为探讨大分子包埋氧化铁微粒溶液用作核磁共振造影增强剂的可能性,测定其铁含量、粘度、密度、分子大小、磁化率等理化性质;在核磁共振诊断仪上测定铁浓度随T1、T2信号强度的变化。结果表明，得到氧化铁微粒溶液的铁浓度为8.5g/L,用电镜测定的颗粒大小为10nm,粘度为0.00168Pa*s,当微粒溶液铁浓度为0.1mmol/L时,T2信号强度的下降大于50%,T1信号强度在铁浓度为0.2—0.4mmol/L时,有一峰值,然后下降。溶液放置1年,无大颗粒和明显沉淀物出现。说明本实验制备的葡聚糖包埋氧化铁溶液颗粒均匀,悬浮性好,在核磁共振诊断仪上显示出,随着铁浓度的增加,T2信号强度下降快,适于用作核磁共振造影的阴性增强剂。
위탐토대분자포매양화철미립용액용작핵자공진조영증강제적가능성,측정기철함량、점도、밀도、분자대소、자화솔등이화성질;재핵자공진진단의상측정철농도수T1、T2신호강도적변화。결과표명，득도양화철미립용액적철농도위8.5g/L,용전경측정적과립대소위10nm,점도위0.00168Pa*s,당미립용액철농도위0.1mmol/L시,T2신호강도적하강대우50%,T1신호강도재철농도위0.2—0.4mmol/L시,유일봉치,연후하강。용액방치1년,무대과립화명현침정물출현。설명본실험제비적포취당포매양화철용액과립균균,현부성호,재핵자공진진단의상현시출,수착철농도적증가,T2신호강도하강쾌,괄우용작핵자공진조영적음성증강제。
The purpose of this article is to determine physical and chemical properties of the iron oxide solution prepared in our laboratory and to evaluate the possibility for using it as a nuclear magnetic resonance contrast agent.The iron concentration and viscosity of the solution were found to be 0.15 mol/L and 0.00168 Pa*s， respectively,the particle size of the iron core was about 10nm determined with a transmission electronic telescope.The susceptibility increased with increasing iron concentration.The T2 signal intensity decreased by more than 50% at iron concentration of 0.1mmol/L,there was a peak of T1 signal intensity at iron concentration of 0.2—0.4mmol/L.No precipitate was observed in the solution after storing for one year.It was concluded good homogeneity and suspensibility of the iron solution were obtained.The significant decrease of T2 signal intensity with iron concentration shows that the solution was a promising contrast agent for magnetic resonance imaging.