CAJ | 학술논문

目的:探讨高血压患者血清肝细胞生长因子(HGF),可溶性细胞间黏附分子-1(sICAM-1)水平的变化及其意义.方法:选择59例高血压患者,其中高血压1级组20例,高血压2级组19例,高血压3级组20例,并选择30例健康体检者作为正常对照组.用酶联免疫双抗体夹心法检测各组血清HGF和sICAM-1浓度,并进行比较.结果:与正常对照组相比,高血压患者血清HGF[(641.65±142.90)pg/ml比(998.15±241.38)pg/ml]、sI-CAM-1[(161.70±32.36)ng/ml比(327.17±31.28)ng/ml]水平明显升高(P＜0.01),血压越高,其变化越显著(P＜0.01),HGF浓度与sICAM-1浓度呈正相关(r=0.317,P＜0.01).结论:HGF与sICAM-1可能参与了高血压的发病过程,而且HGF在高血压内皮细胞损伤的修复中可能具有重要作用.
목적:탐토고혈압환자혈청간세포생장인자(HGF),가용성세포간점부분자-1(sICAM-1)수평적변화급기의의.방법:선택59례고혈압환자,기중고혈압1급조20례,고혈압2급조19례,고혈압3급조20례,병선택30례건강체검자작위정상대조조.용매련면역쌍항체협심법검측각조혈청HGF화sICAM-1농도,병진행비교.결과:여정상대조조상비,고혈압환자혈청HGF[(641.65±142.90)pg/ml비(998.15±241.38)pg/ml]、sI-CAM-1[(161.70±32.36)ng/ml비(327.17±31.28)ng/ml]수평명현승고(P＜0.01),혈압월고,기변화월현저(P＜0.01),HGF농도여sICAM-1농도정정상관(r=0.317,P＜0.01).결론:HGF여sICAM-1가능삼여료고혈압적발병과정,이차HGF재고혈압내피세포손상적수복중가능구유중요작용.
Objective:To study changes of serum levels of hepatocyte growth factor (HGF),soluble intercellular adhesion molecule-1 (sICAM-1) in patients with essential hypertension (EH) and their significance.Methods:A total of 59 EH patients were selected,including 20 cases with EH stage 1 (EH stage 1 group),19 cases with EH stage 2(EH stage 2 group) and 20 cases with EH stage 3 (EH stage 3 group).Another 30 healthy subjects were regard as normal control group.Double antibody enzyme-linked immunosorbent sandwich assay was used to measure concentrations of HGF and sICAM-1 in all groups,and then the results were compared and analyzed.Results:Compared with normal control group,there were significant increase in serum levels of HGF [ (641.65± 142.90) pg/ml vs.(998.15±241.38) pg/ml] and sICAM-1 [ (161.70±32.36) ng/ml vs.(327.17±31.28) ng/ml] in EH patients (P＜0.01 both),and it's more significant as blood pressure increased (P＜0.01).HGF concentration was positively correlated with sICAM-1 concentration (r =0.317,P＜0.01).Conclusion:HGF and sICAM-1 may participate in pathogenesis of hypertension,and HGF may play an important role in restore of impaired endothelial cells in hypertension.