CAJ | 학술논문

目的探讨骨桥蛋白在卵巢上皮癌组织和血清中的表达及意义.方法分别应用免疫组化和ELISA法测定64例卵巢上皮癌患者卵巢组织和血清中骨桥蛋白的表达水平,并与20例卵巢良性肿瘤和10例正常对照患者卵巢组织中的表达水平进行比较.结果卵巢上皮癌患者卵巢组织和血清中骨桥蛋白的表达水平均与疾病临床分期及病理分化程度有关(均P<0.01).骨桥蛋白在卵巢上皮癌组织中的阳性表达率明显高于卵巢良性肿瘤及正常卵巢组织(均P<0.01).结论骨桥蛋白与卵巢上皮癌的发生、发展密苘切相关.
목적 탐토골교단백재란소상피암조직화혈청중적표체급의의.방법분별응용면역조화화ELISA법측정64례란소상피암환자란소조직화혈청중골교단백적표체수평,병여20례란소량성종류화10례정상대조환자란소조직중적표체수평진행비교.결과란소상피암환자란소조직화혈청중골교단백적표체수평균여질병림상분기급병리분화정도유관(균P<0.01).골교단백재란소상피암조직중적양성표체솔명현고우란소량성종류급정상란소조직(균P<0.01).결론골교단백여란소상피암적발생、발전밀경절상관.
Objective To study the expression and signficance of the osteopontin (OPN) in epithelial ovarian cancer tissue and serum. Methods Immunohistochemistry method and ELISA were used to detect the expression of OPN in 64 cases of epithelial ovarian cancer tissue and serum, 20 cases of ovarian benign tumors and 10 cases of ovarian nomal tissues. Results The OPN expression was associated with the clinical staging and histological grading of epithelial ovarian cancer tissue and serum (P < 0.01). The level of OPN in epithelial ovarian cancer tissue was significantly higher than that in benign ovarian tumor and normal control groups (P < 0.01). Conclusion OPN is remarkably correlated with the carcinogenesis and the development of epithelial ovarian cancer.