国际医学寄生虫病杂志
國際醫學寄生蟲病雜誌
국제의학기생충병잡지
INTERNATIONAL JOURNAL OF MEDICAL PARASITIC DISEASES
2011年
5期
265-269
,共5页
江艳%龚仁敏%林矫矫%杨艺%石耀军%陆珂%李浩%朱传刚%徐玉梅%邱叶艳
江豔%龔仁敏%林矯矯%楊藝%石耀軍%陸珂%李浩%硃傳剛%徐玉梅%邱葉豔
강염%공인민%림교교%양예%석요군%륙가%리호%주전강%서옥매%구협염
日本血吸虫%吡喹酮%透皮治疗
日本血吸蟲%吡喹酮%透皮治療
일본혈흡충%필규동%투피치료
Schistosoma japonicum%Praziquantel%Transdermal%treatment
目的 探究吡喹酮(praziquantel,PZQ)透皮剂的治疗效果,以及吡喹酮与宿主免疫系统是否具有协同作用,为治疗血吸虫病提供更便利的治疗途径.方法 新西兰大白兔感染日本血吸虫尾蚴150±2条或300±2条,透皮剂浓度为24％,以100 mg/kg剂量对感染日本血吸虫28 d的新西兰大白兔分别进行腹部透皮治疗1次和2次,并在1次感染和2次感染后1d和14 d透皮治疗2次.统计治疗组的减虫率、肝减卵率、减毛蚴孵化率,评价透皮剂的治疗效果.结果 感染日本血吸虫28 d后吡喹酮透皮剂透皮治疗2次效果优于1次,减虫率分别为96.23％和80.19％,肝减卵率和减毛蚴孵化率均达到或接近100％.对感染后1d和14 d的透皮治疗,感染2次并治疗的减虫率分别为86.62％和91.84％.结论 24％的PZQ透皮制剂具有较好的杀灭日本血吸虫成虫作用,透皮次数越多,治疗效果越好；透皮剂对杀灭日本血吸虫童虫也有一定的作用,对感染2次并治疗的减虫效果更好,可能与感染宿主的免疫协同作用有关.
目的 探究吡喹酮(praziquantel,PZQ)透皮劑的治療效果,以及吡喹酮與宿主免疫繫統是否具有協同作用,為治療血吸蟲病提供更便利的治療途徑.方法 新西蘭大白兔感染日本血吸蟲尾蚴150±2條或300±2條,透皮劑濃度為24％,以100 mg/kg劑量對感染日本血吸蟲28 d的新西蘭大白兔分彆進行腹部透皮治療1次和2次,併在1次感染和2次感染後1d和14 d透皮治療2次.統計治療組的減蟲率、肝減卵率、減毛蚴孵化率,評價透皮劑的治療效果.結果 感染日本血吸蟲28 d後吡喹酮透皮劑透皮治療2次效果優于1次,減蟲率分彆為96.23％和80.19％,肝減卵率和減毛蚴孵化率均達到或接近100％.對感染後1d和14 d的透皮治療,感染2次併治療的減蟲率分彆為86.62％和91.84％.結論 24％的PZQ透皮製劑具有較好的殺滅日本血吸蟲成蟲作用,透皮次數越多,治療效果越好；透皮劑對殺滅日本血吸蟲童蟲也有一定的作用,對感染2次併治療的減蟲效果更好,可能與感染宿主的免疫協同作用有關.
목적 탐구필규동(praziquantel,PZQ)투피제적치료효과,이급필규동여숙주면역계통시부구유협동작용,위치료혈흡충병제공경편리적치료도경.방법 신서란대백토감염일본혈흡충미유150±2조혹300±2조,투피제농도위24％,이100 mg/kg제량대감염일본혈흡충28 d적신서란대백토분별진행복부투피치료1차화2차,병재1차감염화2차감염후1d화14 d투피치료2차.통계치료조적감충솔、간감란솔、감모유부화솔,평개투피제적치료효과.결과 감염일본혈흡충28 d후필규동투피제투피치료2차효과우우1차,감충솔분별위96.23％화80.19％,간감란솔화감모유부화솔균체도혹접근100％.대감염후1d화14 d적투피치료,감염2차병치료적감충솔분별위86.62％화91.84％.결론 24％적PZQ투피제제구유교호적살멸일본혈흡충성충작용,투피차수월다,치료효과월호；투피제대살멸일본혈흡충동충야유일정적작용,대감염2차병치료적감충효과경호,가능여감염숙주적면역협동작용유관.
Objective To explore the treatment effect of praziquantel (PZQ) transdermal agent,and whether praziquantel and host immune system having synergistic effect in treatment of schistosomiasis.Methods The New Zealand white rabbits were infected with Schistosoma japonicum 150 ± 2 or 300 ± 2cercariae.The concentration of transdermal agent was 24％.The rabbits were treated through abdominal transdermal once and twice at the dose of 100 mg/kg on day 28 post infection,or they were treated twice on day 1 or day 14 post infection in secondary infection.Worm reduction rate,egg reduction rate and miracidia hatching reduction rate of treatment groups were calculated to evaluate the therapeutic effect of transdermal agent.Results The effect of praziquantel transdermal therapy twice was better than once on day 28 post infection.Worm reduction rates were 96.23％ and 80.19％ respectively.Egg reduction rate and miracidia reduction rate were at or close to 100％.The worm reduction rates of treatment on day 1 or day 14 after secondary infection were 86.62％ and 91.84％ respectively.Conclusion 24％ of praziquantel transdermal agent had good effect on adult Schistosoma japonicum.The more transdermal therapy times,the better treatment effect.Transdermal agent also had effect on schistosomulum,and had the better worm reduction rate on secondary infection after treatment than first infection,indicating that praziquantel may have immune-synergy effect.
