CAJ | 학술논문

目的了解小儿喘息性疾病人类偏肺病毒(hMPV)感染情况,探讨二者之间关系.方法对124例小儿喘息性疾病患儿鼻咽分泌物分别作7种常见呼吸道病毒[呼吸道合胞病毒(RSV)、流感病毒A、B型、副流感病毒1、2、3型、腺病毒]免疫荧光检测和hMPV逆转录巢式聚合酶链反应(RT-nPCR)特异性基因检测.结果共检测到各种病毒阳性70例,其中7种常见呼吸道病毒阳性53例(42.7%),分别是RSV 39例,流感病毒6例,腺病毒5例,副流感病毒3例;RT-nPCR检测hMPV阳性17例(13.7%),hMPV合并RSV 感染2例;RSV和hMPV感染患儿在年龄、性别、临床症状上无统计学意义(P>0.05).结论 RSV仍是小儿喘息性疾病中最多见病原体,hMPV可能是其发病的又一重要病原体,二者临床特征相似.
목적 료해소인천식성질병인류편폐병독(hMPV)감염정황,탐토이자지간관계.방법 대124례소인천식성질병환인비인분비물분별작7충상견호흡도병독[호흡도합포병독(RSV)、류감병독A、B형、부류감병독1、2、3형、선병독]면역형광검측화hMPV역전록소식취합매련반응(RT-nPCR)특이성기인검측.결과 공검측도각충병독양성70례,기중7충상견호흡도병독양성53례(42.7%),분별시RSV 39례,류감병독6례,선병독5례,부류감병독3례;RT-nPCR검측hMPV양성17례(13.7%),hMPV합병RSV 감염2례;RSV화hMPV감염환인재년령、성별、림상증상상무통계학의의(P>0.05).결론 RSV잉시소인천식성질병중최다견병원체,hMPV가능시기발병적우일중요병원체,이자림상특정상사.
Objective To investigate correlation between human metapneumovirus infection and wheezing Disease in children. Methods Seven common respiratory viruses extracted from nasopharyngeal secretion in 124children with Wheezing diseases were analyzed with immunofluorescent assay. Meanwhile, the hMPV gene was detected with RT-nPCR. Results Seventy positive cases were detected in all patients. Among them, 53(42.7% )were common respiratory viruses (39 Respiratory syncytial viruses RSV, 6 influenza virus, 5 adenovirus and 3 par influenza virus). Meanwhile, hMPV gene were detected in 17 cases (13.7%). 2 patients were infected with both RSV and hMPV. The age, gender and clinical manifestations of the children infected with RSV and with hMPV didnt show significant difference ( P > 0.05 ). Conclusion RSV was still the most commonly virus in children Wheezing Disease. Meanwhile, hMPV was another important pathogen. The clinical characteristics of the two viruses were similar.