国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2012年
1期
15-17
,共3页
郭瑞友%赵丽霞%苏丽%王莉%王彩霞%郭联
郭瑞友%趙麗霞%囌麗%王莉%王綵霞%郭聯
곽서우%조려하%소려%왕리%왕채하%곽련
卒中后抑郁%针刺%瘦素%胰岛素样生长因子-1
卒中後抑鬱%針刺%瘦素%胰島素樣生長因子-1
졸중후억욱%침자%수소%이도소양생장인자-1
Post-strokedepression%Acupuncture%Leptin%IGF-1
目的 探讨针刺治疗对老年卒中后抑郁患者血浆瘦素( leptin)及胰岛素样生长因子-1(IGF-1)的影响.方法 以老年缺血性卒中患者为研究对象,采用汉密尔顿抑郁量表(HAMD)筛选卒中后抑郁患者94例,按病例尾号将患者随机分为两组,全部患者均接受西医常规治疗和二级预防.对照组48例在此基础上口服舍曲林治疗,针刺组46例在对照组治疗基础上采用灵龟八法选穴治疗,两组均治疗6周.分别于治疗前后,检测患者血浆leptin和IGF-1浓度,并进行HAMD量表评估疗效.结果 ①治疗后针刺组血浆leptin与IGF-1浓度[分别为(17.06±12.38) ng/ml、(52.61±24.74) ng/ml]较对照组[分别为(32.27±15.09) ng/ml、(77.15±20.83) ng/ml]明显降低,差异有统计学意义(P＜0.01).②治疗后HAMD评分,针刺组与对照组[分别为(8.06±3.32)分、(13.67±8.05)分]及6个月随访时HAMD评分[分别为(6.52±2.08)分、(10.26±6.16)分]比较,差异均有统计学意义(P＜0.01).结论 针刺治疗可降低卒中后抑郁患者血浆leptin、IGF-1浓度.
目的 探討針刺治療對老年卒中後抑鬱患者血漿瘦素( leptin)及胰島素樣生長因子-1(IGF-1)的影響.方法 以老年缺血性卒中患者為研究對象,採用漢密爾頓抑鬱量錶(HAMD)篩選卒中後抑鬱患者94例,按病例尾號將患者隨機分為兩組,全部患者均接受西醫常規治療和二級預防.對照組48例在此基礎上口服捨麯林治療,針刺組46例在對照組治療基礎上採用靈龜八法選穴治療,兩組均治療6週.分彆于治療前後,檢測患者血漿leptin和IGF-1濃度,併進行HAMD量錶評估療效.結果 ①治療後針刺組血漿leptin與IGF-1濃度[分彆為(17.06±12.38) ng/ml、(52.61±24.74) ng/ml]較對照組[分彆為(32.27±15.09) ng/ml、(77.15±20.83) ng/ml]明顯降低,差異有統計學意義(P＜0.01).②治療後HAMD評分,針刺組與對照組[分彆為(8.06±3.32)分、(13.67±8.05)分]及6箇月隨訪時HAMD評分[分彆為(6.52±2.08)分、(10.26±6.16)分]比較,差異均有統計學意義(P＜0.01).結論 針刺治療可降低卒中後抑鬱患者血漿leptin、IGF-1濃度.
목적 탐토침자치료대노년졸중후억욱환자혈장수소( leptin)급이도소양생장인자-1(IGF-1)적영향.방법 이노년결혈성졸중환자위연구대상,채용한밀이돈억욱량표(HAMD)사선졸중후억욱환자94례,안병례미호장환자수궤분위량조,전부환자균접수서의상규치료화이급예방.대조조48례재차기출상구복사곡림치료,침자조46례재대조조치료기출상채용령구팔법선혈치료,량조균치료6주.분별우치료전후,검측환자혈장leptin화IGF-1농도,병진행HAMD량표평고료효.결과 ①치료후침자조혈장leptin여IGF-1농도[분별위(17.06±12.38) ng/ml、(52.61±24.74) ng/ml]교대조조[분별위(32.27±15.09) ng/ml、(77.15±20.83) ng/ml]명현강저,차이유통계학의의(P＜0.01).②치료후HAMD평분,침자조여대조조[분별위(8.06±3.32)분、(13.67±8.05)분]급6개월수방시HAMD평분[분별위(6.52±2.08)분、(10.26±6.16)분]비교,차이균유통계학의의(P＜0.01).결론 침자치료가강저졸중후억욱환자혈장leptin、IGF-1농도.
Objective To investigate the effects of acupuncture on the serum leptin and IGF-1 in patients with post-stroke depression (PSD).Methods By using Hamilton rating scale for depression (HAMD),94 patients with PSD were recruited and randomly divided into 2 groups:acupuncture group and control group.All patients were given routine clinical treatments and second level medical prevention.Patients in the acupuncture group received Linggui Ba fa acupuncture treatment and oral administration of Sertraline and patients in the control group were treated with oral administration of Sertraline only.Serum levels of letpin and insulin growth factor (IGF-1) were measured by enzyme linked immunosorbent assay (ELISA) before and after treatments in all patients.Results The levels of leptin and IGF-1 in patients of acupuncture group were significantly lower than that of the control group after treatment[(17.06 ± 12.38) ng/ml vs (32.27 ± 15.09)ng/ml,P＜0.01; (52.61±24.74)ng/ml vs (77.15±20.83)ng/ml,P＜0.01 respectively].The scores of HAMD in acupuncture group were significantly lower than that of control group after the treatment[(8.06±3.32)、(13.67±8.05)]and 6 month later[(6.52±2.08)、(10.26±6.16)].Conclusion The serum levels ofleptin and IGF-1 were significantly lower and depression symptoms were improved after acupuncture in elderly patients with post-strok depressin.
