CAJ | 학술논문

目的探讨相对健康的中老年人血清瘦素与脂联素水平与心脑血管疾病危险因素的相关性.方法从"广州生物库队列研究"中收集1515名相对健康的50岁及以上的中老年人个人资料及病史、体格检查并测定血清空腹血糖、血脂、瘦素和脂联素的水平.结果 (1)广州市1515名的血清瘦素水平(x-±s)男女性分别为(3.90±2.36)ng/ml和(12.17±2.01)ng/ml;脂联素水平男女性分别为(5.33±2.78)mg/L和(7.18±2.58)mg/L.(2)男女性血清瘦素和脂联素水平均随年龄增长而升高;在调整BMI后,男性瘦素水平仍随年龄增长而显著升高(趋势检验P＜0.001),而女性其脂联素水平也随年龄增长而显著升高(趋势检验P＜0.05).(3)在调整年龄后,男女性血清瘦素和脂联素水平均与吸烟状态无明显相关(P=0.09～0.76).(4)血清瘦素水平,男女性均随腰围、BMI、SBP、LDL-C和TG增加而显著升高(P=0.04,＜0.001),同时还随男性的DBP和空腹血糖升高及HDL-C降低而显著升高(P=0.03～0.02).(5)血清脂联素水平男女性均随腹围以及TG升高而下降(P=0.003,＜0.001),而男性血清脂联素水平还随BMI与空腹血糖升高及HDL-C水平下降而下降(P=0.05,＜0.001),女性则随SBP和TC上升而下降(P=0.05～0.006).结论广州市相对健康的中老年人血清瘦素和脂联索水平男性比女性低;男性瘦素水平和女性脂联素水平同年龄增加呈显著相关.血清瘦素升高和脂联素下降与传统心脑血管危险因素上升有关.
목적 탐토상대건강적중노년인혈청수소여지련소수평여심뇌혈관질병위험인소적상관성.방법 종"엄주생물고대렬연구"중수집1515명상대건강적50세급이상적중노년인개인자료급병사、체격검사병측정혈청공복혈당、혈지、수소화지련소적수평.결과 (1)엄주시1515명적혈청수소수평(x-±s)남녀성분별위(3.90±2.36)ng/ml화(12.17±2.01)ng/ml;지련소수평남녀성분별위(5.33±2.78)mg/L화(7.18±2.58)mg/L.(2)남녀성혈청수소화지련소수평균수년령증장이승고;재조정BMI후,남성수소수평잉수년령증장이현저승고(추세검험P＜0.001),이녀성기지련소수평야수년령증장이현저승고(추세검험P＜0.05).(3)재조정년령후,남녀성혈청수소화지련소수평균여흡연상태무명현상관(P=0.09～0.76).(4)혈청수소수평,남녀성균수요위、BMI、SBP、LDL-C화TG증가이현저승고(P=0.04,＜0.001),동시환수남성적DBP화공복혈당승고급HDL-C강저이현저승고(P=0.03～0.02).(5)혈청지련소수평남녀성균수복위이급TG승고이하강(P=0.003,＜0.001),이남성혈청지련소수평환수BMI여공복혈당승고급HDL-C수평하강이하강(P=0.05,＜0.001),녀성칙수SBP화TC상승이하강(P=0.05～0.006).결론 엄주시상대건강적중노년인혈청수소화지련색수평남성비녀성저;남성수소수평화녀성지련소수평동년령증가정현저상관.혈청수소승고화지련소하강여전통심뇌혈관위험인소상승유관.
Objective To study the serum leptin and adiponectin levels among relatively healthy older people and their association with traditional cardiovascular risk factors.Methods Personal medical history and blood sample were collected from 1515 older people of Guangzhou.Fasting serum glucose,lipids,leptin and adiponectin were measured.Results(1)In relatively healthy older adults aged 50 or above,from Guangzhou,the following data were seen:serum leptin levels(x-±s)in men and women were(3.90±2.36)ng/ml and(12.17 ±2.01)ng/ml respectively;serum adiponectin levels in men and women were(5.33 ± 2.78)mg/L and(7.18 ± 2.58)mg/L respectively.(2)Serum leptin and adiponectin level increased with age.After adjusting for body mass index,the trend for serum leptin level in men(P＜0.001)and adiponectin level in women(P＜0.05)were significantly associated with age.(3)No association was found between cigarette smoking and levels of leptin or adiponectin in both men and women after adjusting for age(P from 0.09 to 0.76).(4)In both men and women,serum leptin and adiponectin levels were positively associated with waist circumference/body mass index,systolic blood pressure,low-density lipoprotein cholesterol and triglyceride(P from 0.04 to＜0.001).In men,leptin was also significantly associated with the increase of diastolic blood pressure and glucose but decreased with high-density lipoprotein cholesterol(P from 0.03 to 0.02).(5)Decreased adiponectin level was associated with increased waist circumference and triglyceride in both men and women(P from 0.003 to＜0.001)and with the increased body mass index,fasting plasma glucose as well as with decreased high-density lipoprotein cholesterol in men(P from 0.05 to＜0.001)but with increased systolic blood pressure and total cholesterol in women(P from 0.05 to 0.006).Conclusion In Guangzhou city,among relatively healthy older adults aged 50 or above,their serum leptin and adiponectin levels were lower in men than in women.Serum leptin level in men and adiponectin level in women were significantly associated with the increase of age.Increased leptin and decreased adiponectin levels were associated with increased traditional cardiovascular risk factors.